Uric acid levels and cardiovascular and cerebrovascular diseases: a Mendelian randomization study.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY Cerebrovascular Diseases Pub Date : 2024-10-04 DOI:10.1159/000541624

Xiaowen Hou, Kaiwen Cen, Yunfeng Zhu, Zhi Zhu, Zhiyu Zhang, Xu Feng

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Abstract

Introduction: The relationship between uric acid (UA) levels and cardiovascular and cerebrovascular diseases (CCVD) is controversial. A two-sample Mendelian randomization (MR) study was conducted to explore the causal effects of UA levels on CCVD.

Methods: Genetic variants strongly associated with UA levels were selected as instrumental variables from the Genome-Wide Association Study (GWAS) dataset. The GWAS data, sourced from the Global Urate Genetics Consortium (GUGC), comprised a sample size of 110,347 individuals. The selected CCVD outcomes included stroke, coronary artery disease (CAD), as well as atrial fibrillation and flutter. The primary analytical approach employed the inverse-variance weighted (IVW) method, supplemented by MR-Egger and weighted median as complementary methods. Sensitivity analysis was performed to test heterogeneity and pleiotropy.

Results: The MR analysis results indicated a causal association between UA levels and stroke (OR: 1.002; 95% CI: 1.000-1.003; p = 0.036), CAD (OR: 1.118; 95% CI: 1.044-1.197; p = 0.001), as well as atrial fibrillation and flutter (OR: 1.141; 95% CI: 1.037- 1.256; p = 0.007). The results of MR-Egger and weighted median methods confirmed the direction of the IVW results, enhancing the robustness of the findings. No significant anomalies were detected in the sensitivity analysis.

Conclusion: The MR study suggests that UA levels exert causal effects on stroke, CAD, as well as atrial fibrillation and flutter.

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尿酸水平与心脑血管疾病：孟德尔随机研究。

导言：尿酸（UA）水平与心脑血管疾病（CCVD）之间的关系存在争议。为了探讨尿酸水平对心脑血管疾病的因果效应，我们进行了一项双样本孟德尔随机化（MR）研究：方法：从全基因组关联研究（GWAS）数据集中选取与尿酸水平密切相关的基因变异作为工具变量。GWAS 数据来源于全球尿酸遗传学联合会（GUGC），样本量为 110,347 人。选定的慢性心血管疾病结果包括中风、冠状动脉疾病（CAD）以及心房颤动和扑动。主要分析方法采用了逆方差加权法（IVW），并辅以MR-Egger和加权中位数作为补充方法。进行了敏感性分析以检验异质性和多向性：MR分析结果表明，UA水平与中风（OR：1.002；95% CI：1.000-1.003；P = 0.036）、CAD（OR：1.118；95% CI：1.044-1.197；P = 0.001）以及心房颤动和扑动（OR：1.141；95% CI：1.037-1.256；P = 0.007）之间存在因果关系。MR-Egger和加权中位法的结果证实了IVW结果的方向，增强了研究结果的稳健性。敏感性分析未发现明显异常：MR研究表明，UA水平对中风、CAD以及心房颤动和扑动具有因果效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.