{"title":"Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells.","authors":"Phillip P Domeier, Steven F Ziegler","doi":"10.1093/jleuko/qiae216","DOIUrl":null,"url":null,"abstract":"<p><p>Thymic stromal lymphopoietin (TSLP) is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings that underpin our limited understanding of the role TSLP in modulating different stages of B cell development. We will also provide an overview of how TSLP drives B cell-mediated immune disease and how novel TSLP-blocking biologics could be used to modulate B cell responses. TSLP is critical for the regulation, diversity, and longevity of humoral immunity.</p>","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leukocyte Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jleuko/qiae216","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Thymic stromal lymphopoietin (TSLP) is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings that underpin our limited understanding of the role TSLP in modulating different stages of B cell development. We will also provide an overview of how TSLP drives B cell-mediated immune disease and how novel TSLP-blocking biologics could be used to modulate B cell responses. TSLP is critical for the regulation, diversity, and longevity of humoral immunity.
胸腺基质淋巴细胞生成素（TSLP）是一种成熟的多向性警报细胞因子，可在屏障组织中生成，诱导2型免疫反应，但人们对它在调节B细胞多样性方面的作用却知之甚少。在这里，我们将重点介绍一些重要发现，这些发现支撑了我们对 TSLP 在调节 B 细胞发育不同阶段的作用的有限理解。我们还将概述 TSLP 如何驱动 B 细胞介导的免疫疾病，以及新型 TSLP 阻断生物制剂如何用于调节 B 细胞反应。TSLP对于体液免疫的调节、多样性和寿命至关重要。
期刊介绍：
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.
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