Oral Hydrogels that Balance Microbiome for Tumor Treatment.

IF 11 1区 综合性期刊 Q1 Multidisciplinary Research Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.34133/research.0494
Chu Jiang, Huajie Liu, Yinan Zhang
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Abstract

Intervening in the microbial environment holds promise for enhancing antitumor efficacy by reshaping the tumor microenvironment, yet few strategies have been reported. In a study led by Zou and coworkers, oral hydrogels are introduced to regulate the microbiota balance in the intestines and tumors, triggering an antitumor immune response. This work presents a microbiota-targeted drug delivery system that demonstrates notable efficacy in colon targeting and colon retention for the treatment of colorectal cancer. This represents a significant clinical advancement in treating colorectal cancer, which is particularly vulnerable to microbial infiltration.

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平衡微生物群的口腔水凝胶用于肿瘤治疗
干预微生物环境有望通过重塑肿瘤微环境来提高抗肿瘤疗效,但目前报道的策略还很少。在邹和同事领导的一项研究中,通过引入口服水凝胶来调节肠道和肿瘤中的微生物群平衡,从而引发抗肿瘤免疫反应。这项研究提出了一种微生物群靶向给药系统,该系统在结肠靶向和结肠保留治疗结直肠癌方面具有显著疗效。这标志着在治疗结直肠癌方面取得了重大的临床进展,因为结直肠癌特别容易受到微生物浸润的影响。
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来源期刊
Research
Research Multidisciplinary-Multidisciplinary
CiteScore
13.40
自引率
3.60%
发文量
0
审稿时长
14 weeks
期刊介绍: Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.
期刊最新文献
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