Maternal early pregnancy body mass index and risk of insomnia in the offspring.

IF 5.6 2区 医学 Q1 Medicine Sleep Pub Date : 2024-10-07 DOI:10.1093/sleep/zsae236
Mia Q Zhu, Sven Cnattingius, Louise M O'Brien, Eduardo Villamor
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引用次数: 0

Abstract

Study objectives: To investigate the association between maternal early pregnancy body mass index (BMI) and risk of offspring insomnia.

Methods: We conducted a nationwide cohort study among 3,281,803 singleton live births in Sweden born 1983-2015. Using national registries with prospectively recorded information, we followed participants for an insomnia diagnosis from 2 to up to 35 years of age. We compared insomnia risks by early pregnancy BMI categories using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. To assess unmeasured shared familial confounding, we conducted sibling-controlled analyses among 1,724,473 full siblings and studied the relation of maternal full sisters' BMI and insomnia risk in 1,185,998 offspring.

Results: There were 7,154 insomnia diagnoses over a median follow-up age of 17.9 years. Compared with women with normal BMI, adjusted HR (95% CI) of offspring insomnia for early pregnancy BMI categories overweight, obesity class I, and obesity classes II or III were, respectively, 1.22 (1.14, 1.30), 1.60 (1.45, 1.77), and 2.11 (1.83, 2.45). Corresponding adjusted HR (95% CI) in sibling comparisons were, respectively, 1.32 (1.05, 1.65), 1.48 (1.03, 2.14), and 1.56 (0.91, 2.65). Associations with maternal sisters' BMI were attenuated, suggesting a weak role for unmeasured shared factors. Other pregnancy, birth, and neonatal complications were associated with risk of insomnia in offspring but did not substantially mediate the association.

Conclusions: The dose-response relation between maternal overweight and obesity severity with offspring insomnia risk is not fully explained by shared familial factors.

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母亲孕早期体重指数与后代失眠的风险。
研究目的研究母亲孕早期体重指数(BMI)与后代失眠风险之间的关系:我们对瑞典 3,281,803 名 1983-2015 年出生的单胎活产婴儿进行了一项全国性队列研究。我们利用具有前瞻性信息记录的国家登记册,对被诊断为失眠症的参与者进行了从 2 岁到 35 岁的跟踪调查。我们使用调整后的 Cox 模型中的危险比 (HR) 和 95% 置信区间 (CI),比较了怀孕早期 BMI 类别的失眠风险。为了评估未测量的共同家族混杂因素,我们对 1,724,473 名同胞兄弟姐妹进行了同胞对照分析,并研究了 1,185,998 名后代中母亲同胞兄弟姐妹的体重指数与失眠风险的关系:在 17.9 岁的中位随访年龄中,共有 7,154 例失眠诊断。与体重指数正常的女性相比,妊娠早期体重指数超重、肥胖 I 级、肥胖 II 级或 III 级的后代失眠调整 HR(95% CI)分别为 1.22(1.14,1.30)、1.60(1.45,1.77)和 2.11(1.83,2.45)。在同胞比较中,相应的调整HR(95% CI)分别为1.32(1.05,1.65)、1.48(1.03,2.14)和1.56(0.91,2.65)。与母亲姐妹体重指数的关系减弱,表明未测量的共同因素作用微弱。其他妊娠、分娩和新生儿并发症与后代的失眠风险有关,但并未在很大程度上介导这种关联:结论:母亲超重和肥胖严重程度与后代失眠风险之间的剂量-反应关系并不能完全由共同的家族因素解释。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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