MORTALITY AND CARDIOVASCULAR RISK REDUCTION AFTER REVERSION OF PREDIABETES TO NORMOGLYCEMIA: A SYSTEMATIC REVIEW.

IF 0.7 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Acta Endocrinologica-Bucharest Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI:10.4183/aeb.2024.74
A Hengky, K G Pratama, K Tandarto
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Abstract

Introduction: It is unclear whether reversion to normoglycemia decreases overall cardiovascular events and all-cause mortality risk in the long term. We aim to investigate the magnitude of change in cardiovascular risk and mortality in patients who reverted from a prediabetes state.

Methods: Three electronic databases, including PubMed, Proquest, and EBSCOHost databases, were utilized. A manual hand search of articles was also done. We selected studies that measure cardiovascular risk and all-cause mortality risk after reversion from prediabetes to normoglycemia. The following terms and its variant were used in the search strategy: 'reversion,' 'prediabetes,' 'normoglycemia,' cardiovascular risk,' and 'mortality.'

Results: Seven studies with a total of 73,845 participants were obtained. Most studies suggest that reversion of prediabetes reduced the cardiovascular and all-cause mortality risk (RR: 0.50 - 0.78) compared to persistent prediabetes state or progression to diabetes with long-term follow-up ranging from 5 to 12 years, while two studies did not show significant association in CVD and all-cause morality risk.

Conclusion: Although there were mixed results regarding if prediabetes poses a higher risk than normoglycemia for cardiovascular events and all-cause mortality, measures to normalize blood glucose for prediabetes should still be advocated.

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糖尿病前期恢复正常血糖后死亡率和心血管风险的降低:系统综述。
导言:长期来看,恢复正常血糖是否会降低总体心血管事件和全因死亡率风险尚不清楚。我们旨在研究从糖尿病前期状态恢复的患者心血管风险和死亡率的变化幅度:我们使用了三个电子数据库,包括 PubMed、Proquest 和 EBSCOHost 数据库。我们还对文章进行了人工检索。我们选取了测量从糖尿病前期转为正常血糖后心血管风险和全因死亡风险的研究。搜索策略中使用了以下术语及其变体:"逆转"、"糖尿病前期"、"正常血糖"、"心血管风险 "和 "死亡率":共获得七项研究,参与人数达 73845 人。大多数研究表明,在5至12年的长期随访中,与糖尿病前期状态持续存在或发展为糖尿病相比,糖尿病前期的逆转可降低心血管疾病和全因死亡率风险(RR:0.50 - 0.78),而两项研究并未显示心血管疾病和全因死亡率风险的显著相关性:尽管关于糖尿病前期是否比正常血糖对心血管事件和全因死亡率构成更高风险的研究结果不一,但仍应提倡采取措施使糖尿病前期患者的血糖恢复正常。
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来源期刊
Acta Endocrinologica-Bucharest
Acta Endocrinologica-Bucharest 医学-内分泌学与代谢
CiteScore
1.30
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Acta Endocrinologica (Buc) is an international journal covering the fields of basic and clinical Endocrinology, Neuroendocrinology, Reproductive Medicine, Chronobiology, Human Ethology published quarterly Acta Endocrinologica (Buc) is the official international journal of the Romanian Society for Endocrinology. It continues the former Romanian Journal of Endocrinology
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