Breaking a dogma: orthodontic tooth movement alters systemic immunity.

IF 4.8 2区 医学 Q1 Dentistry Progress in Orthodontics Pub Date : 2024-10-07 DOI:10.1186/s40510-024-00537-z
Yehuda Klein, Eilon David, Noy Pinto, Yasmin Khoury, Yechezkel Barenholz, Stella Chaushu
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Abstract

Background: The prevailing paradigm posits orthodontic tooth movement (OTM) as primarily a localized inflammatory process. In this study, we endeavor to elucidate the potential ramifications of mechanical force on systemic immunity, employing a time-dependent approach.

Materials and methods: A previously described mouse orthodontic model was used. Ni-Ti. springs were set to move the upper 1st-molar in C57BL/6 mice and the amount of OTM was. measured by µCT. Mice were allocated randomly into four experimental groups, each. corresponding to clinical phases of OTM, relative to force application. Terminal blood. samples were collected and a comprehensive blood count test for 7 cell types as well as. proteome profiling of 111 pivotal cytokines and chemokines were conducted. Two controls. groups were included: one comprised non-treated mice and the other mice with inactivated springs.

Results: Serum immuno-profiling unveiled alterations in cellular immunity, manifesting as. changes in percentages of leukocytes, monocytes, macrophages, neutrophils, and. lymphocytes, alongside key signaling factors in comparison to both control groups. The systemic cellular and molecular alterations triggered by OTM mirrored the dynamics previously described in the local immune response.

Conclusions: Although the exact interplay between local and systemic immune responses to orthodontic forces require further elucidation, our findings demonstrate a tangible link between the two. Future investigations should aim to correlate these results with human subjects, and strive to delve deeper into the specific mechanisms by which mechanical force modulates the systemic immune response.

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打破教条:正畸牙齿移动会改变全身免疫力。
背景:目前流行的观点认为正畸牙齿移动(OTM)主要是一种局部炎症过程。在本研究中,我们采用一种时间依赖性方法,努力阐明机械力对全身免疫的潜在影响:材料和方法:我们使用了之前描述过的小鼠正畸模型。使用镍钛弹簧移动 C57BL/6 小鼠的上第一臼齿,并通过 µCT 测量 OTM 的量。小鼠被随机分配到四个实验组,每组对应于相对于施力的 OTM 临床阶段。收集终末血液样本,对 7 种细胞类型进行全面的血细胞计数检测,并对 111 种关键细胞因子和趋化因子进行蛋白质组分析。研究还包括两个对照组:一组是未接受治疗的小鼠,另一组是接受灭活弹簧治疗的小鼠:与两个对照组相比,血清免疫分析揭示了细胞免疫的变化,表现为白细胞、单核细胞、巨噬细胞、中性粒细胞和淋巴细胞百分比的变化,以及关键信号因子的变化。OTM引发的全身细胞和分子变化反映了之前在局部免疫反应中描述的动态变化:尽管还需要进一步阐明局部和全身免疫反应对正畸力的确切相互作用,但我们的研究结果表明两者之间存在着切实的联系。未来的研究应旨在将这些结果与人类受试者进行关联,并努力深入研究机械力调节全身免疫反应的具体机制。
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来源期刊
Progress in Orthodontics
Progress in Orthodontics Dentistry-Orthodontics
CiteScore
7.30
自引率
4.20%
发文量
45
审稿时长
13 weeks
期刊介绍: Progress in Orthodontics is a fully open access, international journal owned by the Italian Society of Orthodontics and published under the brand SpringerOpen. The Society is currently covering all publication costs so there are no article processing charges for authors. It is a premier journal of international scope that fosters orthodontic research, including both basic research and development of innovative clinical techniques, with an emphasis on the following areas: • Mechanisms to improve orthodontics • Clinical studies and control animal studies • Orthodontics and genetics, genomics • Temporomandibular joint (TMJ) control clinical trials • Efficacy of orthodontic appliances and animal models • Systematic reviews and meta analyses • Mechanisms to speed orthodontic treatment Progress in Orthodontics will consider for publication only meritorious and original contributions. These may be: • Original articles reporting the findings of clinical trials, clinically relevant basic scientific investigations, or novel therapeutic or diagnostic systems • Review articles on current topics • Articles on novel techniques and clinical tools • Articles of contemporary interest
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