{"title":"Problems with Fenner and Marshall’s method of estimating myxoma virus virulence delayed a closer understanding of rabbit-virus coevolution","authors":"Brian Cooke","doi":"10.1071/hr24010","DOIUrl":null,"url":null,"abstract":"<p>When myxoma virus was first released in Australia it was seen not only as a means of controlling rabbits but also an opportunity to understand the evolution of a disease in a new host. The virus quickly attenuated into less virulent variants while simultaneously rabbits built heritable resistance to the disease. Nonetheless, rather than rabbits quickly outstripping virus virulence, myxoma viruses have adapted and kept pace with increases in rabbit resistance by increasing in virulence and other attributes necessary for remaining highly transmissible. As well as benefitting the biological control of pest rabbits, this previously unrevealed chapter details the evolution of myxomatosis while also documenting the delays in reaching a consensus on the coevolution of myxoma virus virulence and rabbit resistance.</p>","PeriodicalId":51246,"journal":{"name":"Historical Records of Australian Science","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Historical Records of Australian Science","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.1071/hr24010","RegionNum":4,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HISTORY & PHILOSOPHY OF SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
When myxoma virus was first released in Australia it was seen not only as a means of controlling rabbits but also an opportunity to understand the evolution of a disease in a new host. The virus quickly attenuated into less virulent variants while simultaneously rabbits built heritable resistance to the disease. Nonetheless, rather than rabbits quickly outstripping virus virulence, myxoma viruses have adapted and kept pace with increases in rabbit resistance by increasing in virulence and other attributes necessary for remaining highly transmissible. As well as benefitting the biological control of pest rabbits, this previously unrevealed chapter details the evolution of myxomatosis while also documenting the delays in reaching a consensus on the coevolution of myxoma virus virulence and rabbit resistance.
期刊介绍：
Historical Records of Australian Science is a bi-annual journal that publishes two kinds of unsolicited manuscripts relating to the history of science, pure and applied, in Australia, New Zealand and the southwest Pacific.
Historical Articles–original scholarly pieces of peer-reviewed research
Historical Documents–either hitherto unpublished or obscurely published primary sources, along with a peer-reviewed scholarly introduction.
The first issue of the journal (under the title Records of the Australian Academy of Science), appeared in 1966, and the current name was adopted in 1980.
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