Platelet aggregates in lung capillaries in severely decompensated pulmonary hypertension

IF 9 1区 医学 Q1 RESPIRATORY SYSTEM Thorax Pub Date : 2024-10-07 DOI:10.1136/thorax-2024-222034
Camille Miard, Vincent Thomas de Montpreville, Jean-François Bernaudin, Julien Adam, Chakib Djediat, Francois Stephan
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Abstract

The mechanism of thrombocytopenia during acute pulmonary hypertension (PH) decompensation may be partly due to platelet aggregation in the lung. Platelet aggregates in explanted lung from 16 lung transplant patients during acute PH decompensation with and without thrombocytopenia were identified by immunohistochemistry. Scanning electron microscopy (SEM) was performed. 7 explant lung controls without PH and thrombocytopenia were also examined. Compared with controls, the median number of platelet aggregates was higher in patients with acute PH decompensation with thrombocytopenia (19.4 [IQR 3.4–38.3] vs 147.5 [IQR 26.5–203.2]). SEM showed capillaries filled with platelet aggregates. Our study suggests that platelets may aggregate in the lungs during acute PH decompensation.
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严重失代偿肺动脉高压患者肺毛细血管中的血小板聚集
急性肺动脉高压(PH)失代偿期血小板减少的部分原因可能是肺内血小板聚集。通过免疫组化鉴定了 16 名急性肺动脉高压失代偿期伴有血小板减少症和不伴有血小板减少症的肺移植患者切除肺中的血小板聚集。进行了扫描电子显微镜(SEM)检查。同时还检测了 7 例无 PH 和血小板减少的肺移植对照组。与对照组相比,急性 PH 失代偿伴血小板减少患者的血小板聚集中位数更高(19.4 [IQR 3.4-38.3] vs 147.5 [IQR 26.5-203.2])。扫描电子显微镜显示毛细血管充满血小板聚集。我们的研究表明,在 PH 急性失代偿期,血小板可能在肺部聚集。
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来源期刊
Thorax
Thorax 医学-呼吸系统
CiteScore
16.10
自引率
2.00%
发文量
197
审稿时长
1 months
期刊介绍: Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.
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