{"title":"Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption","authors":"Senegal Carty","doi":"10.1038/s41574-024-01048-x","DOIUrl":null,"url":null,"abstract":"<p>Efferent nerves from the dorsal motor nucleus of the vagus (DMV) connect to the gastrointestinal system and are thought to regulate digestion. The mechanisms by which the DMV controls nutrient absorption are under active investigation. A study published in <i>Nature</i> shows that a subpopulation of DMV neurons controls intestinal dietary fat absorption by modulating microvillus length in the jejunum.</p><p>The researchers then searched for a pharmacological means of inhibiting DMV activity by performing electrophysiology on mouse brainstem slices exposed to different molecules of interest. This approach revealed that the isoflavanoid puerarin suppressed DMV activity. “Moreover, photo-affinity labelling was used to identify proteins that bind to puerarin,” say authors Qianqian Lyu, Wenzhi Xue, Chunlei Zhang and Jiqiu Wang. The results suggested that puerarin might target GABRA1, a subunit of the inhibitory receptor GABA<sub>A</sub>.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41574-024-01048-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Efferent nerves from the dorsal motor nucleus of the vagus (DMV) connect to the gastrointestinal system and are thought to regulate digestion. The mechanisms by which the DMV controls nutrient absorption are under active investigation. A study published in Nature shows that a subpopulation of DMV neurons controls intestinal dietary fat absorption by modulating microvillus length in the jejunum.
The researchers then searched for a pharmacological means of inhibiting DMV activity by performing electrophysiology on mouse brainstem slices exposed to different molecules of interest. This approach revealed that the isoflavanoid puerarin suppressed DMV activity. “Moreover, photo-affinity labelling was used to identify proteins that bind to puerarin,” say authors Qianqian Lyu, Wenzhi Xue, Chunlei Zhang and Jiqiu Wang. The results suggested that puerarin might target GABRA1, a subunit of the inhibitory receptor GABAA.
期刊介绍:
Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.