LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-10-08 DOI:10.1002/alz.14265

Amber Watts, Amanda Szabo-Reed, Jordan Baker, Jill K. Morris, James Vacek, Jonathan Clutton, Jonathan Mahnken, Mickeal N. Key, Eric D. Vidoni, Jeffrey M. Burns

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Abstract

INTRODUCTION

Clinicians lack the tools to incorporate physical activity into clinical care for Alzheimer's disease prevention. We tested a 52-week exercise and health education program (Lifestyle Empowerment for Alzheimer's Prevention [LEAP! Rx]) that integrates clinician referrals and community-based fitness resources.

METHODS

We randomized 219 participants to the LEAP! Rx (ie, exercise and monthly brain health education) or a standard-of-care control group and tested the effects on cardiorespiratory fitness, insulin resistance, body composition, lipids, and cognitive performance.

RESULTS

Physicians were able to connect their patients to a community lifestyle intervention. The intervention group increased in cardiorespiratory fitness at 12 and 52 weeks (p = 0.005). We observed no effects on secondary measures. Participants meeting 80% of weekly goals (150 min, moderate to vigorous activity) saw greater fitness improvements than those with less than 80% (p < 0.001).

DISCUSSION

These results hold promise for broad implementation of exercise interventions into larger healthcare systems and have implications for improved research recruitment strategies.

TRIAL REGISTRATION

NCT No. NCT03253341.

Highlights

Our community-based exercise program increased cardiorespiratory fitness.
Our digital physician referral method increased the diversity of the participant sample.
Our findings have implications for personalized dementia risk reduction strategies.

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LEAP！Rx：生活方式医学实用方法随机试验

临床医生缺乏将体育锻炼纳入阿尔茨海默病预防临床护理的工具。我们测试了一项为期 52 周的运动和健康教育计划（阿尔茨海默氏症预防生活方式赋能计划 [LEAP!Rx]），该计划整合了临床医生转诊和社区健身资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.