Yu-Lin Lu, Ya-Ping Wang, Kai Wu, Mei Pan, Cheng-Yong Su
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引用次数: 0
Abstract
The emulation of ingenious biofunctions has been a research focus for several decades. Metal–organic cages (MOCs), as a type of discrete supramolecular assembly with well-defined shapes and cavities, have aroused great interest in chemists to imitate natural protein cages or enzymes. However, to genuinely achieve tailored functionalities or reactivities of enzymes, the design of cage structures combining both the confined microenvironment and the active site is a prerequisite. Therefore, the integration of functionalized motifs into MOCs is expected to provide a feasible approach to construct biofunctional confined nanospaces, which not only allows the modulation of cage properties for applications such as molecular recognition, transport, and catalysis but also creates unique microenvironments that promote enzymatic effects for special reactivities and selectivities, thereby providing a versatile platform to achieve exceptional biomimetic functions and beyond.
几十年来，模拟巧妙的生物功能一直是研究的重点。金属有机笼（MOCs）作为一种具有明确形状和空腔的离散超分子组装体，引起了化学家们对模仿天然蛋白质笼或酶的极大兴趣。然而，要真正实现酶的定制功能或反应活性，先决条件是设计出兼具封闭微环境和活性位点的笼状结构。因此，将功能化图案整合到 MOC 中有望为构建生物功能性密闭纳米空间提供一种可行的方法，这不仅可以调节笼子的特性，用于分子识别、传输和催化等应用，还可以创造独特的微环境，促进酶效应，实现特殊的反应性和选择性，从而为实现特殊的生物仿生功能及其他功能提供一个多功能平台。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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