Bidirectional Elastic PTFE Small Diameter Artificial Blood Vessel Grafts and Surface Antithrombotic Functionalized Construction.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-10-21 Epub Date: 2024-10-09 DOI:10.1021/acsabm.4c01098

Siqi Zhou, Yulu Liu, Xueke Yu, Dongfang Wang, Xiaofeng Wang, Qian Li

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Abstract

Expanded polytetrafluoroethylene (ePTFE) failed to achieve clinical application in the field of small-diameter blood vessels due to its lack of elasticity in the circumferential direction and high stiffness. Excellent multidirectional elasticity and dynamic compliance matching with natural blood vessels are important means to solve the problem of acute thrombosis and poor long-term patency. Herein, novel PTFE spinning blood vessels were prepared by the PTFE emulsion electrospinning process, which not only presented good bidirectional elasticity but also promoted the adhesion and proliferation of endothelial cells and induced the contractile expression of SMCs. And, a PTFE-shish and aminated polycaprolactone (PCL)-kebab structure has been developed that converted the chemically inert PTFE surface into a drug-loading platform for the multifunctionalization of PTFE vascular grafts. It provides novel preparation methods for the application of new bidirectional elastic small-diameter artificial blood vessels and their surface functionalization construction.

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双向弹性聚四氟乙烯小直径人造血管移植物和表面抗血栓功能化结构。

膨体聚四氟乙烯（ePTFE）由于缺乏圆周方向的弹性和高硬度，未能在小直径血管领域实现临床应用。与天然血管相匹配的优异多向弹性和动态顺应性是解决急性血栓形成和长期通畅性差问题的重要手段。本文采用聚四氟乙烯乳液电纺丝工艺制备了新型聚四氟乙烯纺丝血管，不仅具有良好的双向弹性，还能促进内皮细胞的粘附和增殖，诱导 SMC 的收缩表达。此外，还开发了一种聚四氟乙烯-shish 和胺化聚己内酯（PCL）-kebab 结构，将化学惰性的聚四氟乙烯表面转化为药物负载平台，实现了聚四氟乙烯血管移植物的多功能化。它为新型双向弹性小直径人造血管的应用及其表面功能化构建提供了新颖的制备方法。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.