Zirconium(IV) coordination-mediated rapid and versatile post-modification of polydopamine coating as stationary phase for open-tubular capillary electrochromatography

IF 3.8 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of Chromatography A Pub Date : 2024-10-02 DOI:10.1016/j.chroma.2024.465415
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Abstract

In recent years, mussel-inspired polydopamine (PDA)-based materials have attracted significant attention in the field of open-tubular capillary electrochromatography (OT-CEC) owing to their diverse and appealing properties. However, previously established functionalized PDA coating-based CEC stationary phases predominantly relied on the latent reactivity of PDA with amine/thiol-containing molecules, limiting the types of applicable modifiers and requiring time-consuming reaction processes. Herein, we presented a versatile and efficient method for the facile and rapid fabrication of diverse functionalized PDA coatings as OT-CEC stationary phases through a Zr(IV) coordination-mediated post-modification strategy. Different kinds of modifiers, including octadecylamine (ODA), lauric acid (LA), and perfluorooctanoic acid (PFOA), were rapidly and robustly grafted onto the PDA coating, verified through multiple characterization techniques. The influences of preparation parameters on the grafting efficiency of the functionalized PDA coating were systematically investigated. Utilizing the Zr(IV)-mediated ODA-, LA- and PFOA-functionalized PDA-based OT-CEC columns, we achieved high-efficiency baseline separation of a series of neutral analytes with excellent repeatability, good stability, and long lifetime. Given the strong universality of the Zr(IV) coordination-mediated post-modification approach, our study provides an effective pathway for advancing the development of a wider range of functional PDA-based chromatographic stationary phases.
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锆(IV)配位介导的聚多巴胺涂层快速、多功能后改性,作为开放管式毛细管电色谱的固定相。
近年来,基于贻贝启发的聚多巴胺(PDA)材料因其多样化的诱人特性,在开放管状毛细管电色谱(OT-CEC)领域引起了极大关注。然而,以前建立的基于 PDA 涂层的功能化 CEC 固定相主要依赖于 PDA 与含胺/硫醇分子的潜在反应性,从而限制了适用改性剂的类型,并且需要耗时的反应过程。在此,我们提出了一种多功能、高效的方法,通过 Zr(IV)配位介导的后改性策略,方便、快速地制备出多种功能化 PDA 涂层,作为 OT-CEC 固定相。不同种类的改性剂,包括十八胺(ODA)、月桂酸(LA)和全氟辛酸(PFOA),被快速而牢固地接枝到 PDA 涂层上,并通过多种表征技术进行了验证。系统研究了制备参数对功能化 PDA 涂层接枝效率的影响。利用 Zr(IV)介导的 ODA、LA 和 PFOA 功能化 PDA 基 OT-CEC 色谱柱,我们实现了一系列中性分析物的高效基线分离,并具有优异的重复性、良好的稳定性和较长的使用寿命。鉴于 Zr(IV)配位介导的后修饰方法具有很强的通用性,我们的研究为推动更广泛的基于 PDA 的功能性色谱固定相的开发提供了有效途径。
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来源期刊
Journal of Chromatography A
Journal of Chromatography A 化学-分析化学
CiteScore
7.90
自引率
14.60%
发文量
742
审稿时长
45 days
期刊介绍: The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.
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