Association of Parental Interactions and Therapies with Cerebral Oxygenation Variability in the Neonatal Intensive Care Unit.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY American journal of perinatology Pub Date : 2024-10-29 DOI:10.1055/a-2435-1066

Presley Volkema, Lisa Letzkus, Michael Spaeder, Santina Zanelli

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Abstract

Objective: This study evaluated the association of parental interactions and therapies with cerebral oxygenation (rScO₂) and rScO₂ variability in infants using near-infrared spectroscopy.

Study design: Prospective pilot study in clinically stable infants admitted to the neonatal intensive care unit (NICU). Infants were monitored continuously for 48 hours, and rScO₂ during parental interactions and therapies was compared with periods of no activity. rScO₂ variability was derived using the root mean of successive squared differences of averaged 1-minute rScO₂ values. Wilcoxon matched-pairs signed-rank test was used to compare baseline and activity periods.

Results: Data analysis included 23 infants. rScO₂ variability increased during periods of parental interaction (p = 0.04) and during combined parental interaction and therapies (p = 0.04).

Conclusion: We observed that routine NICU interventions are associated with increased rScO₂ variability in clinically stable NICU patients. rScO₂ variability may represent a useful biomarker for the early determination of the safety and efficacy of NICU interventions.

Key points: · Low rScO2 variability is linked to poor outcomes.. · Parental interactions increase rScO2 variability.. · rScO2 variability may be a useful biomarker.. · rScO2 variability may predict outcomes..

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新生儿重症监护室中父母互动和疗法与脑氧合变异的关系

研究目的使用近红外光谱（NIRS）评估父母互动和疗法与婴儿脑氧合（CrSO2）和 CrSO2 变异性的关系：前瞻性试验研究：针对入住新生儿重症监护室（NICU）、临床病情稳定的婴儿。对婴儿进行 48 小时的连续监测，并将父母互动和治疗期间的 CrSO2 与无活动期间的 CrSO2 进行比较。CrSO2 变异性是通过平均 1 分钟 CrSO2 值的连续平方差的根平均值得出的。Wilcoxon 配对符号秩检验用于比较基线期和活动期：数据分析包括 23 名婴儿。在父母互动期间（p=0.04）和父母互动与治疗相结合期间（p=0.04），CrSO2 变异性增加：我们观察到，新生儿重症监护室的常规干预措施与临床稳定的新生儿重症监护室患者 CrSO2 变异性的增加有关。CrSO2 变异性可能是早期确定新生儿重症监护室干预措施安全性和有效性的有用生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.