The gut microbiota as a link between Alzheimer's disease and obesity.

IF 3.9 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY American journal of physiology. Gastrointestinal and liver physiology Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI:10.1152/ajpgi.00174.2024
Karla Lucia F Alvarez, Gonzalo Davila-Del-Carpio
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Abstract

Alzheimer's disease (AD) is a degenerative disease that causes a progressive decline in memory and thinking skills. Over the past few years, diverse studies have shown that there is no single cause of AD; instead, it has been reported that factors such as genetics, lifestyle, and environment contribute to the pathogenesis of the disease. In this sense, it has been shown that obesity during middle age is one of the most prominent modifiable risk factors for AD. Of the multiple potential mechanisms linking obesity and AD, the gut microbiota (GM) has gained increasing attention in recent years. However, the underlying mechanisms that connect the GM with the process of neurodegeneration remain unclear. Through this narrative review, we present a comprehensive understanding of how alterations in the GM of people with obesity may result in systemic inflammation and affect pathways related to the pathogenesis of AD. We conclude with an analysis of the relationship between GM and insulin resistance, a risk factor for AD that is highly prevalent in people with obesity. Understanding the crosstalk between obesity, GM, and the pathogenesis of AD will help to design new strategies aimed at preventing neurodegeneration.

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小评论:肠道微生物群是阿尔茨海默病与肥胖之间的联系。
阿尔茨海默病(AD)是一种退行性疾病,会导致记忆力和思维能力逐渐衰退。在过去的几年里,各种研究表明,阿尔茨海默病的病因并不单一;相反,据报道,遗传、生活方式和环境等因素都是该病的发病机制。从这个意义上讲,中年肥胖已被证明是导致注意力缺失症最主要的可改变风险因素之一。在肥胖与注意力缺失症的多种潜在关联机制中,肠道微生物群(GM)近年来越来越受到关注。然而,将肠道微生物群与神经退行性变过程联系起来的潜在机制仍不清楚。通过这篇叙述性综述,我们全面了解了肥胖症患者肠道微生物群的改变是如何导致全身性炎症并影响与阿兹海默症发病机制相关的途径的。最后,我们分析了肥胖症基因组与胰岛素抵抗之间的关系,而胰岛素抵抗是肥胖症患者中非常普遍的一种导致注意力缺失症的风险因素。了解肥胖、胰岛素抵抗和注意力缺失症发病机制之间的相互关系将有助于设计旨在预防神经变性的新策略。
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来源期刊
CiteScore
9.40
自引率
2.20%
发文量
104
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Gastrointestinal and Liver Physiology publishes original articles pertaining to all aspects of research involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. Authors are encouraged to submit manuscripts dealing with growth and development, digestion, secretion, absorption, metabolism, and motility relative to these organs, as well as research reports dealing with immune and inflammatory processes and with neural, endocrine, and circulatory control mechanisms that affect these organs.
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