Mechanisms of erectile dysfunction induced by aging: A comprehensive review.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-09 DOI:10.1111/andr.13778

Baojun Zhuang, Chenglin Zhuang, Yongze Jiang, Jingyi Zhang, Yandong Zhang, Peihai Zhang, Xujun Yu, Suyun Xu

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Abstract

Background: With the increasing trend ofpopulation aging, erectile dysfunction (ED) among elderly men has emerged as apressing health concern. Despite extensive research on the relationship betweenED and aging, ongoing discoveries and evidence continue to arise.

Objective: Through this comprehensiveanalysis, we aim to provide a more nuanced theoretical framework for thedevelopment of preventive and therapeutic strategies for senile ED, ultimatelyenhancing the quality of life for elderly men.

Methods: This review delves deeper into thecore mechanisms underlying ED in the context of aging and offers acomprehensive overview of published meta-analyses and systematic reviewspertinent to these conditions.

Results and conclusion: Our findings revealthat local structural damage to the penis, vascular dysfunction, neuronalinjury, hormonal alterations, other physiological changes, and psychologicalbarriers all play pivotal roles in the pathogenesis of aging-related ED.Furthermore, more than 20 diseases closely associated with aging have beenimplicated in the occurrence of ED, further compounding the complexity of thisissue.

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老化诱发勃起功能障碍的机制：全面回顾。

背景：随着人口老龄化趋势的加剧，老年男性勃起功能障碍（ED）已成为一个令人担忧的健康问题。尽管对 ED 与衰老之间的关系进行了广泛的研究，但仍不断有新的发现和证据出现：通过这一综合分析，我们旨在为老年性 ED 的预防和治疗策略的开发提供一个更细致的理论框架，最终提高老年男性的生活质量：方法：本综述深入探讨了老年性 ED 的核心机制，并对已发表的与这些疾病相关的荟萃分析和系统综述进行了全面概述：我们的研究结果表明，阴茎局部结构损伤、血管功能障碍、神经元损伤、荷尔蒙改变、其他生理变化和心理障碍都在与衰老相关的 ED 的发病机制中起着关键作用。此外，有 20 多种与衰老密切相关的疾病被认为与 ED 的发生有关，这进一步加剧了这一问题的复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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