Congenital Anomalies of the Gastrointestinal Tract in Conjunction of Congenital Heart Diseases in Infants With Trisomy 21

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY Birth Defects Research Pub Date : 2024-10-09 DOI:10.1002/bdr2.2406

Allison M. Peluso, Mohsen A. A. Farghaly, Hany Aly, Mohamed A. Mohamed

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Abstract

Background

Infants with Trisomy 21 are known to have increased incidence congenital anomalies including congenital heart diseases (CHD) and congenital gastrointestinal anomalies. It is not known if there are patterns of coexistence.

Objectives

To examine the coexistence of CHD with various gastrointestinal anomalies in infants with Trisomy 21.

Methods

We assessed a sample of infants with Trisomy 21 from the National Inpatient Sample (NIS), and its KID subversion, produced by the Healthcare Cost and Utilization Project for 2003–2015. We identified CHD using international classification of diseases version 9 (ICD9) and categorized them into four groups: left sided lesions, right sided lesions, conotruncal lesions, and shunt lesions. We identified small intestinal atresia and Hirschsprung disease with ICD9 codes.

Results

The sample included 81,561 newborn infants diagnosed with Trisomy 21; 45% of them had CHD; 4.7% had small intestinal atresia, and 1.6% had Hirschsprung disease. All subcategories of CHD were associated with increased incidence of both small intestinal atresia and Hirschsprung disease, p value < 0.05 compared to infants with Trisomy 21 who did not have CHD.

Conclusions

Among infants with Trisomy 21, the presence of CHD increased the odds of a concomitant congenital GI anomaly.

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21 三体综合征婴儿先天性胃肠道畸形与先天性心脏病并发症。

背景：众所周知，21 三体综合征婴儿的先天性畸形发病率较高，包括先天性心脏病（CHD）和先天性胃肠道畸形。目前尚不清楚是否存在共存模式：研究 21 三体综合征婴儿的先天性心脏病与各种胃肠道畸形并存的情况：我们评估了2003-2015年全国住院病人样本（NIS）及其KID子版本中的21三体综合征婴儿样本，该样本由医疗成本与利用项目（Healthcare Cost and Utilization Project）编制。我们使用国际疾病分类第 9 版（ICD9）确定了先天性心脏病，并将其分为四组：左侧病变、右侧病变、锥体病变和分流病变。我们用 ICD9 编码识别了小肠闭锁和赫氏prung 病：结果：样本包括 81561 名确诊为 21 三体综合征的新生儿，其中 45% 患有先天性心脏病，4.7% 患有小肠闭锁，1.6% 患有赫氏普隆病。所有子类别的先天性心脏病都与小肠闭锁和赫氏普隆病的发病率增加有关，P 值为结论：在 21 三体综合征婴儿中，存在先天性心脏病会增加同时出现先天性消化道异常的几率。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.