Magnitude of multiple drug use and determinants of vulnerability among chronic kidney disease inpatients in Ethiopia: a multi-center study.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY BMC Nephrology Pub Date : 2024-10-07 DOI:10.1186/s12882-024-03773-x
Tirsit Ketsela Zeleke, Rahel Belete Abebe, Samuel Agegnew Wondm, Bantayehu Addis Tegegne
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Abstract

Background: Patients with chronic kidney disease frequently face various nutritional and metabolic problems that necessitate the use of multiple medications. This multiple drug use can lead to several drug-related problems including adverse drug events, hospital admissions, poor medication adherence, harmful drug interactions, inadequate therapeutic outcomes, and death. Despite these challenges, there is a notable lack of studies on the extent of multiple drug use and its determinants among patients with chronic kidney disease in Ethiopia. This study aims to assess the magnitude of multiple drug use and identify the determinants of vulnerability among patients with chronic kidney disease in Ethiopia.

Method: A hospital-based cross-sectional study was conducted among patients with chronic kidney disease. Eligible participants were selected using a simple random sampling technique. Frequency and percentage calculations were performed for categorical variables, while means and standard deviations were used for continuous variables. The chi-square test and t-test were used to compare the proportions and means, respectively. Binary logistic regression was used to identify the determinants of multiple drug use, with statistical significance determined by a p-value of less than 0.05 and a 95% confidence interval. Guidelines and previous literature were utilized to assess the magnitude of multiple drug use.

Results: A total of 230 patients were enrolled, with more than half being male. The overall magnitude of multiple drug use was 83.0%. Diuretics being the most frequently prescribed medication class followed by angiotensin converting enzyme inhibitors. Patients aged 65 years and above (AOR = 4.91 (95% CI 1.60-15.03)), CKD stage five (AOR) = 5.48 (95% CI 1.99-15.09)), and the presence of comorbid conditions (AOR) = 3.53 (95% CI 1.55-8.06)) were significantly associated with multiple drug use.

Conclusion: Chronic kidney disease patients exhibited a high rate of multiple drug use. The presence of comorbid conditions, disease progression and older age are significant determinates of this vulnerability. Health care providers should pay particular attention to these factors to manage and mitigate the risks associated with multiple drug use.

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埃塞俄比亚慢性肾病住院病人使用多种药物的程度及其易感性的决定因素:一项多中心研究。
背景:慢性肾病患者经常面临各种营养和代谢问题,因此需要使用多种药物。多重用药可导致多种与药物相关的问题,包括药物不良事件、入院、用药依从性差、有害的药物相互作用、治疗效果不佳以及死亡。尽管存在这些挑战,但有关埃塞俄比亚慢性肾病患者多重用药的程度及其决定因素的研究却明显不足。本研究旨在评估埃塞俄比亚慢性肾脏病患者使用多种药物的程度,并确定其脆弱性的决定因素:在慢性肾病患者中开展了一项基于医院的横断面研究。采用简单随机抽样技术选取了符合条件的参与者。分类变量采用频率和百分比计算,连续变量采用平均值和标准差计算。比例和均值的比较分别采用卡方检验和 t 检验。使用二元逻辑回归来确定多重吸毒的决定因素,统计意义由小于 0.05 的 p 值和 95% 的置信区间决定。利用指南和以往文献来评估多重用药的程度:共有 230 名患者入选,其中一半以上为男性。多重用药的总体比例为 83.0%。利尿剂是最常用的处方药,其次是血管紧张素转换酶抑制剂。65 岁及以上患者(AOR = 4.91 (95% CI 1.60-15.03))、慢性肾脏病五期(AOR)= 5.48 (95% CI 1.99-15.09))和合并症(AOR)= 3.53 (95% CI 1.55-8.06))与多重用药显著相关:结论:慢性肾脏病患者的多重用药率很高。结论:慢性肾脏病患者的多重用药率很高,并发症的存在、疾病的进展和年龄的增大是导致这种脆弱性的重要因素。医疗服务提供者应特别关注这些因素,以管理和降低与多重用药相关的风险。
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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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