Investigation of Clinical Value of NKT-like Cells in Tumor Diseases.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2024-10-01 DOI:10.7754/Clin.Lab.2024.240509

Yingying Chen, Xinhong Yang, Cuihong Gu, Zhihua Zhang, Xiaofeng Yang

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Abstract

Background: The goal is to study the changes of natural killer T-like (NKT-like) cells with age and explore the value of NKT-like cell changes in the evaluation of immune function and prognosis of tumor patients.

Methods: From January 2021 to December 2021, 19 patients with lung cancer, 37 patients with lymphoma, 16 patients with multiple myeloma (MM), 13 patients with acute lymphoblastic leukemia (ALL), 70 patients with acute myeloid leukemia (AML) treated in the Affiliated Hospital of Chengde Medical College and 141 healthy volunteers included in the healthy control group were recruited to study the change trend of NKT-like cells with age and changes in different tumor patients.

Results: With the increase of age, NKT-like cells in peripheral blood increased gradually in healthy people, mainly composed of CD8+NKT-like cells and CD8-CD4-NKT-like cells. The proportion of NKT-like cells in the lymphoma group and AML group was significantly higher than that in the control group (p < 0.05). The proportion of CD8+NKT-like cells decreased in the Lymphoma, AML, ALL, and lung cancer groups (p < 0.05), there was no statistical significance between MM group and control group (p > 0.05).

Conclusions: With the increase of age, NKT-like cells in peripheral blood gradually increased in healthy people and were mainly composed of CD8+NKT-like cells and CD8-CD4-NKT-like cells. The increase of CD8+NKT-like cells in peripheral blood has important reference value for the evaluation of immune function and prognosis of patients with lymphoma, AML, ALL, and lung cancer and provides direction for immunotherapy.

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研究 NKT 样细胞在肿瘤疾病中的临床价值

背景：目的是研究自然杀伤T样细胞（NKT样细胞）随年龄的变化，探讨NKT样细胞的变化在评估肿瘤患者免疫功能和预后方面的价值：目的：研究自然杀伤T样细胞（NKT样细胞）随年龄的变化，探讨NKT样细胞变化在评价肿瘤患者免疫功能和预后中的价值：方法：自2021年1月至2021年12月，招募承德医学院附属医院收治的19例肺癌患者、37例淋巴瘤患者、16例多发性骨髓瘤（MM）患者、13例急性淋巴细胞白血病（ALL）患者、70例急性髓系白血病（AML）患者以及健康对照组的141名健康志愿者，研究NKT样细胞随年龄的变化趋势以及不同肿瘤患者NKT样细胞的变化情况：结果：随着年龄的增长，健康人外周血中的NKT样细胞逐渐增多，主要由CD8+NKT样细胞和CD8-CD4-NKT样细胞组成。淋巴瘤组和 AML 组的 NKT 样细胞比例明显高于对照组（P < 0.05）。淋巴瘤组、AML组、ALL组和肺癌组的CD8+NKT样细胞比例下降（P＜0.05），MM组与对照组之间无统计学意义（P＞0.05）：结论：随着年龄的增长，健康人外周血中的NKT样细胞逐渐增多，主要由CD8+NKT样细胞和CD8-CD4-NKT样细胞组成。外周血中CD8+NKT样细胞的增加对淋巴瘤、AML、ALL和肺癌患者的免疫功能和预后评估具有重要的参考价值，并为免疫治疗提供了方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.