Lipidomics in Periodontal Disease Research: A Systematic Review.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2024-10-08 DOI:10.2174/0109298673323591240923051742
Carolina Silva, Francisco Peixoto, Isabel Dias, Rosário Domingues, Carlos Viegas
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Abstract

Introduction/objective: Periodontal disease is a highly prevalent oral pathology in the human population, which has a significant local and systemic impact. Currently, multi-omics analyses, including lipidomics, are fundamental to obtaining an in-depth molecular understanding of the individual. Lipidomics is dedicated to the study of lipid species and their interactions in various health contexts. This specific multi-omics analysis is important for understanding the alteration of metabolism and signaling in disease, identifying biochemical markers, and potential therapeutic targets. This study aimed to carry out a systematic review of the existing scientific literature on lipidomics in periodontal disease and thus determine which molecules have already been analyzed and their potential in this specific disease.

Methods: This study followed the recommendations of the PRISMA 2020 methodology. The inclusion criteria used were articles published in indexed journals between 2000 and 2023, written in English, and establishing an exclusive relationship about lipidomics in human periodontal disease. The articles were searched in three different databases.

Results: Considering the criteria defined, only six articles were selected and zed individually in detail. In four of the six studies, differences in the lipidome of individuals with periodontal disease were identified. Furthermore, phosphoethanolamine ceramide was found to have potential as a diagnostic biomarker. Finally, the therapeutic potential of a lipoxin A4 analogue was also identified.

Conclusion: These results reinforce the need for future research in this area so that the consequences of this disease on the lipidome can be identified.

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牙周病研究中的脂质组学:系统综述
导言/目的:牙周病是人类高发的口腔疾病,对局部和全身都有重大影响。目前,包括脂质组学在内的多组学分析是深入了解个体分子情况的基础。脂质组学致力于研究脂质物种及其在各种健康状况下的相互作用。这种特定的多组学分析对于了解疾病中代谢和信号的改变、确定生化标志物和潜在的治疗靶点非常重要。本研究旨在对现有关于牙周病脂质组学的科学文献进行系统回顾,从而确定哪些分子已被分析,以及它们在这种特定疾病中的潜力:本研究遵循 PRISMA 2020 方法的建议。纳入标准为 2000 年至 2023 年期间发表在索引期刊上的文章,以英语撰写,并建立了关于人类牙周病脂质组学的排他性关系。文章在三个不同的数据库中进行了检索:结果:根据所定义的标准,只有六篇文章被选中并逐一进行了详细研究。在这六篇研究中,有四篇发现了牙周病患者脂质体的差异。此外,研究还发现磷脂酰乙醇胺神经酰胺具有作为诊断生物标志物的潜力。最后,还发现了一种脂质毒素 A4 类似物的治疗潜力:这些结果加强了今后在这一领域开展研究的必要性,以便确定这种疾病对脂质体的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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