Early life exposures and risk of inflammatory bowel disease: A nested case-control study in Quebec, Canada.

IF 4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Digestive and Liver Disease Pub Date : 2024-10-07 DOI:10.1016/j.dld.2024.09.011
Canisius Fantodji, Marie-Claude Rousseau, Belinda Nicolau, Sreenath Madathil, Andrea Benedetti, Prévost Jantchou
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Abstract

Background: Early life factors for inflammatory bowel disease are likely to impact the gut microbiota.

Aim: We investigated the associations between early exposures and inflammatory bowel disease.

Methods: This case-control study was nested within the CO·MMUNITY cohort. Cases of Crohn's disease (CD) and ulcerative colitis (UC) were identified using validated algorithms. All cases and randomly selected controls were invited to complete a questionnaire including early life exposures. Analyses were conducted by logistic regression and causal mediation (direct/indirect effects for passive/active smoking).

Results: Early introduction of solid foods at 3-6 months tended to increase CD risk compared to later introduction (>6 months): OR = 1.23; 95 % CI: 0.96-1.56, but not of UC. Exclusive breastfeeding tended to decrease the risk of CD (OR = 0.77; 95 % CI: 0.55-1.08), less so for UC. Antibiotics tended to decrease CD (OR = 0.89; 95 % CI: 0.74-1.07) and UC (OR = 0.88; 95 % CI: 0.71-1.09). No association was found between pets and CD or UC. Passive smoking increased CD risk (OR = 1.23; 95 % CI: 1.00-1.51), 20 % of which was mediated by active smoking, but not UC.

Conclusion: Differences were noticed in early risk factors for CD and UC. The impact of passive smoking was largely independent of active smoking, highlighting its importance for prevention.

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早期生活暴露与炎症性肠病的风险:加拿大魁北克巢式病例对照研究。
背景:炎症性肠病的早期生活因素可能会影响肠道微生物群:目的:我们研究了早期暴露与炎症性肠病之间的关联:这项病例对照研究嵌套在 CO-MUNITY 队列中。采用经过验证的算法确定克罗恩病(CD)和溃疡性结肠炎(UC)病例。邀请所有病例和随机抽取的对照组填写一份问卷,内容包括早期生活暴露。通过逻辑回归和因果中介(被动/主动吸烟的直接/间接影响)进行分析:与较晚引入固体食物(>6 个月)相比,早期引入固体食物(3-6 个月)往往会增加 CD 风险:OR=1.23;95 % CI:0.96-1.56,但 UC 的风险并不增加。纯母乳喂养往往会降低 CD 的风险(OR = 0.77;95 % CI:0.55-1.08),而 UC 的风险则较低。抗生素可降低 CD(OR = 0.89;95 % CI:0.74-1.07)和 UC(OR = 0.88;95 % CI:0.71-1.09)的发病风险。宠物与 CD 或 UC 之间没有关联。被动吸烟会增加 CD 风险(OR = 1.23;95 % CI:1.00-1.51),其中 20 % 是由主动吸烟引起的,但不会增加 UC 风险:结论:CD和UC的早期风险因素存在差异。被动吸烟的影响在很大程度上与主动吸烟无关,这凸显了被动吸烟对预防的重要性。
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来源期刊
Digestive and Liver Disease
Digestive and Liver Disease 医学-胃肠肝病学
CiteScore
6.10
自引率
2.20%
发文量
632
审稿时长
19 days
期刊介绍: Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.
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