Persistence of subcutaneous versus intravenous infliximab in a real-life cohort: A propensity-score matched comparative analysis.

IF 4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Digestive and Liver Disease Pub Date : 2024-10-07 DOI:10.1016/j.dld.2024.09.015
L Bothorel, D Laharie, F Poullenot, E Gohier, C Chevrier, A Berger, F Zerbib, P Rivière
{"title":"Persistence of subcutaneous versus intravenous infliximab in a real-life cohort: A propensity-score matched comparative analysis.","authors":"L Bothorel, D Laharie, F Poullenot, E Gohier, C Chevrier, A Berger, F Zerbib, P Rivière","doi":"10.1016/j.dld.2024.09.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is limited comparative data on patients with inflammatory bowel disease (IBD) switched from intravenous to subcutaneous infliximab and those continuing intravenously. This study aimed to compare the persistence and tolerance of subcutaneous and intravenous infliximab and the outcomes of patients resuming intravenous infliximab.</p><p><strong>Methods: </strong>We conducted a retrospective single-centre cohort study involving IBD patients treated with maintenance intravenous infliximab. The switch to subcutaneous infliximab was offered to patients in clinical remission receiving an intravenous dose ≤ 10 mg kg<sup>-1</sup> every ≥ 6 weeks. The switch group was compared to controls remaining on intravenous infliximab due to refusal of the switch.</p><p><strong>Results: </strong>With a median follow-up of 59 (46-67) weeks, subcutaneous infliximab was discontinued in 28/282 (10 %) patients and intravenous infliximab in 1/78 (1 %) patient (p = 0.01); after propensity score-matching of the two cohorts, persistence rates at 52 weeks were respectively 91 % (95 % CI 84-98) and 100 % (95 % CI 100-100, p = 0.01). Among the 28 who discontinued subcutaneous infliximab, 27 resumed intravenous infliximab, with 4 (1 % of the switch group) who permanently stopped infliximab.</p><p><strong>Conclusion: </strong>Switching from intravenous to subcutaneous infliximab led to a lower treatment persistance. In cases of poor tolerance or relapse under subcutaneous infliximab, resuming intravenous infliximab is effective.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.dld.2024.09.015","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: There is limited comparative data on patients with inflammatory bowel disease (IBD) switched from intravenous to subcutaneous infliximab and those continuing intravenously. This study aimed to compare the persistence and tolerance of subcutaneous and intravenous infliximab and the outcomes of patients resuming intravenous infliximab.

Methods: We conducted a retrospective single-centre cohort study involving IBD patients treated with maintenance intravenous infliximab. The switch to subcutaneous infliximab was offered to patients in clinical remission receiving an intravenous dose ≤ 10 mg kg-1 every ≥ 6 weeks. The switch group was compared to controls remaining on intravenous infliximab due to refusal of the switch.

Results: With a median follow-up of 59 (46-67) weeks, subcutaneous infliximab was discontinued in 28/282 (10 %) patients and intravenous infliximab in 1/78 (1 %) patient (p = 0.01); after propensity score-matching of the two cohorts, persistence rates at 52 weeks were respectively 91 % (95 % CI 84-98) and 100 % (95 % CI 100-100, p = 0.01). Among the 28 who discontinued subcutaneous infliximab, 27 resumed intravenous infliximab, with 4 (1 % of the switch group) who permanently stopped infliximab.

Conclusion: Switching from intravenous to subcutaneous infliximab led to a lower treatment persistance. In cases of poor tolerance or relapse under subcutaneous infliximab, resuming intravenous infliximab is effective.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
现实生活队列中皮下注射与静脉注射英夫利西单抗的持久性:倾向分数匹配比较分析。
背景:关于炎症性肠病(IBD)患者从静脉注射英夫利西单抗转为皮下注射英夫利西单抗和继续静脉注射英夫利西单抗的比较数据有限。本研究旨在比较皮下注射和静脉注射英夫利西单抗的持续性和耐受性,以及恢复静脉注射英夫利西单抗的患者的治疗效果:我们进行了一项回顾性单中心队列研究,涉及接受静脉注射英夫利西单抗维持治疗的 IBD 患者。每≥6周接受静脉注射剂量≤10 mg kg-1的临床缓解期患者可改用皮下注射英夫利西单抗。转换组与因拒绝转换而继续静脉注射英夫利西单抗的对照组进行了比较:中位随访59(46-67)周,28/282(10%)例患者停用皮下注射英夫利西单抗,1/78(1%)例患者停用静脉注射英夫利西单抗(P = 0.01);两组患者倾向得分匹配后,52周时的持续率分别为91%(95% CI 84-98)和100%(95% CI 100-100,P = 0.01)。在停用皮下注射英夫利昔单抗的28人中,27人恢复了静脉注射英夫利昔单抗,4人(占转换组的1%)永久停用了英夫利昔单抗:结论:从静脉注射英夫利西单抗转为皮下注射英夫利西单抗的治疗持续率较低。结论:从静脉注射转为皮下注射英夫利昔单抗可降低治疗的持续性,在皮下注射英夫利昔单抗耐受性差或复发的情况下,恢复静脉注射英夫利昔单抗是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Digestive and Liver Disease
Digestive and Liver Disease 医学-胃肠肝病学
CiteScore
6.10
自引率
2.20%
发文量
632
审稿时长
19 days
期刊介绍: Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.
期刊最新文献
Small bowel metastasis from pulmonary pleomorphic carcinoma. Mannitol for bowel preparation: Efficacy and safety results from the SATISFACTION randomised clinical trial. Dexamethasone improves clinical and biological tolerance of transcatheter arterial chemoembolization for hepatocellular carcinoma. Enhanced bowel prep quality with 1L-PEG vs 2L-PEG and picosulphate: Real-world retrospective study. Exploring the role of fatty acid esters of hydroxy fatty acids in metabolic dysfunction-associated steatotic liver disease in morbidly obese women.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1