Can immuno-PCR (IPCR) transform bacterial disease diagnostics?

IF 3.9 3区 医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-10-09 DOI:10.1080/14737159.2024.2413556
Marcia Ashmi, Changchunzi He, Francis Drobniewski
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Abstract

Introduction: Approximately 15 million deaths occur globally each year due to infectious diseases. Timely diagnosis is crucial in promoting cure and preventing disease transmission. Currently, molecular diagnostics have replaced many conventional diagnostic tools due to their inherent limitations. However, the full potential of Immuno Polymerase Chain Reaction (IPCR) remains largely untapped.

Areas covered: This review focuses on the use of IPCR in the diagnosis of different bacterial diseases, highlighting its advantages over traditional methods.

Expert opinion: Early and accurate diagnosis of infectious diseases is crucial because it enhances treatment effectiveness, reduces morbidity and mortality, helps identify potential causes of sepsis earlier, and reduces the risk of unknowingly spreading the disease to others. IPCR in turn has shown promise for the early diagnosis of bacterial diseases as an alternative to conventional culture-based or serological diagnostic assays leading to delayed diagnosis and treatment. IPCR has the potential to revolutionize the diagnostic field due to its increased sensitivity and specificity. Although efforts are needed to reduce the time of the assay and to reduce background noise, IPCR can be combined with other platforms like lateral flow assay/biosensors/automation to improve its use as a point-of-care assay, especially in resource-limited settings.

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免疫 PCR (IPCR) 能否改变细菌疾病诊断方法?
导言:全球每年约有 1500 万人死于传染病。及时诊断对促进治愈和预防疾病传播至关重要。目前,分子诊断因其固有的局限性已取代了许多传统诊断工具。然而,免疫聚合酶链反应(IPCR)的全部潜力在很大程度上仍未得到开发:本综述侧重于 IPCR 在不同细菌性疾病诊断中的应用,重点介绍 IPCR 与传统方法相比的优势:专家观点:传染病的早期准确诊断至关重要,因为它能提高治疗效果,降低发病率和死亡率,有助于及早发现败血症的潜在病因,并降低在不知情的情况下将疾病传染给他人的风险。IPCR 在细菌性疾病的早期诊断方面也大有可为,它可以替代传统的基于培养或血清学的诊断方法,从而避免延误诊断和治疗。IPCR 具有更高的灵敏度和特异性,有可能在诊断领域掀起一场革命。虽然还需要努力缩短检测时间和减少背景噪音,但 IPCR 可以与横向流检测/生物传感器/自动化等其他平台相结合,以改进其作为护理点检测的使用,尤其是在资源有限的环境中。
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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
71
审稿时长
1 months
期刊介绍: Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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