Impact of augmentation strategy variations on the mechanical characteristics of patients with osteoporotic proximal humerus fractures with medial column instability.

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.3389/fbioe.2024.1463047
Guoqing Xiao, Xiang Zhang, Alin Duan, Jian Li, Jialei Chen
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Abstract

Introduction: Low bone density and lack of medial support are the two most important factors affecting the stability of locking plate fixation for osteoporotic proximal humeral fractures (PHFs). This study aimed to compare the biomechanical characteristics of PHILOS locking plates combined with calcar screws, bone cement, fibular allografts, and medial locking plate support strategies for treating osteoporotic PHFs with medial column instability.

Methods: A three-part osteoporotic PHF (AO 11-B3.2) model with metaphyseal loss was generated using 40 synthetic humeri and fixed via four distinct medial support strategies. All models were mechanically tested to quantify the mechanical characteristics. Subsequently, finite element models were created for each biomechanical test case. The stress distribution and displacement of the four different fixation structures were analyzed using finite element analysis.

Results: The results demonstrated that the PHILOS locking plate combined with the medial locking plate, exhibited the greatest stability when subjected to axial, shear, and torsional loading. Furthermore, the PHILOS locking plate combined with bone cement showed structural stability similar to that of the PHILOS locking plate combined with fibular allograft but with lower stress levels on the fracture surface.

Discussion: In conclusion, the PLP-MLP fixation structure showed superior biomechanical properties under axial, shear, and torsional loading compared to other medial support methods. Repairing the medial support when treating osteoporotic PHFs with medial column instability can enhance the mechanical stability of the fracture end in both the short and long term.

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增强策略变化对骨质疏松性肱骨近端骨折伴内侧柱不稳定患者机械特征的影响。
导言:骨密度低和缺乏内侧支撑是影响锁定钢板固定治疗骨质疏松性肱骨近端骨折(PHF)稳定性的两个最重要因素。本研究旨在比较 PHILOS 锁定钢板结合腓骨螺钉、骨水泥、腓骨异体移植和内侧锁定钢板支撑策略治疗骨质疏松性肱骨近端骨折(PHF)的生物力学特性:使用 40 个合成肱骨制作了一个由三部分组成的骨质疏松 PHF(AO 11-B3.2)模型,并通过四种不同的内侧支撑策略进行固定。对所有模型进行了机械测试,以量化其机械特性。随后,为每个生物力学测试案例创建了有限元模型。使用有限元分析方法对四种不同固定结构的应力分布和位移进行了分析:结果表明,在承受轴向、剪切和扭转载荷时,PHILOS 锁定钢板与内侧锁定钢板组合表现出最大的稳定性。此外,结合骨水泥的 PHILOS 锁定钢板与结合腓骨同种异体移植的 PHILOS 锁定钢板显示出相似的结构稳定性,但骨折表面的应力水平较低:总之,与其他内侧支撑方法相比,PLP-MLP 固定结构在轴向、剪切和扭转负荷下显示出更优越的生物力学特性。在治疗骨质疏松伴有内侧柱不稳定的 PHF 时,修复内侧支撑可在短期和长期内增强骨折端的机械稳定性。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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