Personality and COMT gene: molecular-genetic and epigenetic associations with NEO-PI-R personality domains and facets in monozygotic twins.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY Frontiers in Genetics Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.3389/fgene.2024.1455872

Dušanka Mitrović, Snežana Smederevac, Lissette Delgado-Cruzata, Selka Sadiković, Dejan Pajić, Mechthild Prinz, Zoran Budimlija, Milan Oljača, Jelena Kušić-Tišma, Nataša Vučinić, Aleksandra Milutinović

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Abstract

Background: This study investigates the relationship between MB-COMT DNA methylation (DNAm) and the personality traits outlined in the NEO-PI-R model through an epigenetic study of monozygotic twins. DNAm, a critical epigenetic mechanism, regulates gene expression and has been linked to various biological processes and disorders. By leveraging the genetic similarities of monozygotic twins, this research explores how epigenetic variations influenced by environmental factors correlate with personality differences.

Methods: The study utilized the Five-Factor Model (FFM) to categorize personality traits into five domains: Neuroticism, Extraversion, Conscientiousness, Agreeableness, and Openness to Experience. Each domain comprises six facets, providing a granular view of personality. The research centered on the catechol-O-methyltransferase (COMT) gene, focusing on its role in dopamine metabolism, which is hypothesized to influence personality traits through the dopaminergic system. DNAm status in the MB-COMT promoter region was examined to determine its association with personality facets.

Results: Preliminary findings suggest a complex interaction between MB-COMT DNAm patterns and personality traits. Specific methylation patterns at different CpG sites were linked to varying expressions of traits such as impulsivity and aggression, highlighting the nuanced impact of epigenetics on personality.

Conclusion: This study underscores the potential of integrating genetic, epigenetic, and environmental data to enhance our understanding of personality formation. The results contribute to a broader understanding of how genetic predispositions shaped by environmental factors manifest in complex trait differences, paving the way for future research in genetic psychiatry and personalized medicine.

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人格与 COMT 基因：单卵双生子中 NEO-PI-R 人格领域和方面的分子遗传学和表观遗传学关联。

研究背景本研究通过对单卵双生子进行表观遗传学研究，探讨 MB-COMT DNA 甲基化（DNAm）与 NEO-PI-R 模型中概述的人格特质之间的关系。DNAm 是一种关键的表观遗传机制，它能调节基因表达，并与各种生物过程和疾病有关。本研究利用单卵双生子的遗传相似性，探讨受环境因素影响的表观遗传变异如何与人格差异相关联：研究利用五因素模型（FFM）将人格特质分为五个领域：方法：研究利用五因素模型（FFM）将人格特质分为五个领域：神经质、外向性、自觉性、宜人性和经验开放性。每个领域包括六个方面，提供了人格的细化视角。研究以儿茶酚-O-甲基转移酶（COMT）基因为中心，重点关注该基因在多巴胺代谢中的作用，假设该基因通过多巴胺能系统影响人格特质。研究人员检测了 MB-COMT 启动子区域的 DNAm 状态，以确定其与人格特质的关联：初步研究结果表明，MB-COMT DNAm 模式与人格特质之间存在复杂的相互作用。不同 CpG 位点的特定甲基化模式与冲动性和攻击性等性格特征的不同表现形式有关，突出了表观遗传学对性格的细微影响：结论：这项研究强调了整合遗传、表观遗传和环境数据的潜力，以加深我们对人格形成的理解。研究结果有助于我们更广泛地了解环境因素形成的遗传倾向如何表现为复杂的特质差异，为未来遗传精神病学和个性化医学的研究铺平了道路。

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.