{"title":"Loperamide induced acute pancreatitis in pediatrics.","authors":"G Bruno, G Marinotti","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Presentation: </strong>A 13-year-old boy was admitted to the hospital following an accidental ingestion of 12 mg of loperamide hydrochloride. His main complaint was abdominal pain, especially in his right hypochondrium and epigastrium.</p><p><strong>Diagnosis: </strong>He was diagnosed with acute pancreatitis secondary to the use of loperamide. His lipase and amylase were indeed raised showing an acute and reversible trend. Infections and cholelithiasis were ruled out by blood tests and US abdomen.</p><p><strong>Treatment: </strong>The patient was treated with a single dose of activated charcoal and improved with no further treatment.</p><p><strong>Discussion: </strong>Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptor. This causes spasms and dysfunction of the sphincter of Oddi resulting in obstruction of the pancreatic drainage and leading to acute pancreatitis. This case report shows the first case of loperamide induced acute pancreatitis in pediatrics.</p>","PeriodicalId":14713,"journal":{"name":"Irish medical journal","volume":"117 8","pages":"1016"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish medical journal","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Presentation: A 13-year-old boy was admitted to the hospital following an accidental ingestion of 12 mg of loperamide hydrochloride. His main complaint was abdominal pain, especially in his right hypochondrium and epigastrium.
Diagnosis: He was diagnosed with acute pancreatitis secondary to the use of loperamide. His lipase and amylase were indeed raised showing an acute and reversible trend. Infections and cholelithiasis were ruled out by blood tests and US abdomen.
Treatment: The patient was treated with a single dose of activated charcoal and improved with no further treatment.
Discussion: Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptor. This causes spasms and dysfunction of the sphincter of Oddi resulting in obstruction of the pancreatic drainage and leading to acute pancreatitis. This case report shows the first case of loperamide induced acute pancreatitis in pediatrics.
期刊介绍：
Since its inception in 1867, the Journal of the Medical Association of Ireland and now in its present format, the Irish Medical Journal, has provided the medical community in Ireland with an invaluable service. As one of the leading biomedical publications in Ireland, it has sought to continue the education of medical students and postgraduates through scientific research, review articles and updates on contemporary clinical practices while providing an ongoing forum for medical debate. A measure of our stature is that we are listed in the Index Medicus and issued annually with a citation factor from the Institute for Scientific Information.
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