Physical activity, metabolites, and breast cancer associations.

IF 9.9 1区 医学 Q1 ONCOLOGY JNCI Journal of the National Cancer Institute Pub Date : 2024-10-09 DOI:10.1093/jnci/djae246
Eleanor L Watts, Steven C Moore, Leila Abar, Hyokyoung G Hong, Pedro F Saint-Maurice, Caitlin O'Connell, Charles E Matthews, Erikka Loftfield
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Abstract

Background: The effects of usual physical activity on physiology and disease prevention are not fully understood. We examined the associations between physical activity, metabolites, and breast cancer risk.

Methods: Physical activity levels were assessed using doubly labeled water, accelerometers, and 24-hr recalls in the IDATA study (N = 707 participants, ages 50-74 years, 51% women), with 1-6 assessments over 12 months and two blood sample collections. Partial Spearman correlations were used to estimate associations between physical activity and 843 serum metabolites, corrected for multiple testing. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of metabolites with postmenopausal breast cancer in a nested case-control study (621 cases, 621 controls), all statistical tests were 2-sided.

Results: Physical activity was associated with 164 metabolites spanning numerous pathways, including amino acid and fatty acid metabolism. Twelve of these metabolites were also associated with breast cancer risk, ten of which supported a protective role of physical activity. Notably, higher physical activity was associated with lower 16alpha-hydroxy DHEA 3-sulfate (androgen) and adipoylcarnitine (fatty acid), both of which were associated with increased breast cancer risk (OR per 1 standard deviation (SD)=1.34, 95% CI = 1.16-1.55 and 1.26,1.11-1.42, respectively). Higher physical activity energy expenditure was also associated with lower sphingomyelin (d18:1/20:1, d18:2/20:0), which was associated with a reduced breast cancer risk (0.82,0.73-0.93).

Conclusion: Physical activity is associated with a broad range of metabolites, many of which are consistent with a protective effect against breast cancer. Our findings highlight potential metabolic pathways for cancer prevention.

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体育锻炼、代谢物与乳腺癌的关系。
背景:通常的体育锻炼对生理和疾病预防的影响还不完全清楚。我们研究了体力活动、代谢物和乳腺癌风险之间的关系:方法:在 IDATA 研究(参与者人数为 707 人,年龄在 50-74 岁之间,51% 为女性)中,使用双标记水、加速度计和 24 小时回顾法对体力活动水平进行了评估,在 12 个月内进行了 1-6 次评估,并采集了两次血样。采用部分斯皮尔曼相关性来估计体育锻炼与 843 种血清代谢物之间的关系,并对多重测试进行校正。在一项巢式病例对照研究(621 例病例,621 例对照)中,采用条件逻辑回归模型估算代谢物与绝经后乳腺癌的几率比(ORs)和 95% 置信区间(CIs),所有统计检验均为双侧检验:结果表明:体育锻炼与 164 种代谢物有关,这些代谢物涉及多种途径,包括氨基酸和脂肪酸代谢。其中 12 种代谢物还与乳腺癌风险有关,其中 10 种代谢物支持体育锻炼的保护作用。值得注意的是,体力活动量越大,16α-羟基 DHEA 3-硫酸盐(雄激素)和脂肪酰肉碱(脂肪酸)的含量就越低,而这两种物质都与乳腺癌风险的增加有关(OR 每 1 标准差(SD)=1.34,95% CI = 1.16-1.55 和 1.26,1.11-1.42)。较高的体力活动能量消耗也与较低的鞘磷脂(d18:1/20:1, d18:2/20:0)有关,而鞘磷脂与乳腺癌风险的降低有关(0.82,0.73-0.93):结论:体育锻炼与多种代谢物有关,其中许多代谢物具有预防乳腺癌的作用。我们的研究结果突显了预防癌症的潜在代谢途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
17.00
自引率
2.90%
发文量
203
审稿时长
4-8 weeks
期刊介绍: The Journal of the National Cancer Institute is a reputable publication that undergoes a peer-review process. It is available in both print (ISSN: 0027-8874) and online (ISSN: 1460-2105) formats, with 12 issues released annually. The journal's primary aim is to disseminate innovative and important discoveries in the field of cancer research, with specific emphasis on clinical, epidemiologic, behavioral, and health outcomes studies. Authors are encouraged to submit reviews, minireviews, and commentaries. The journal ensures that submitted manuscripts undergo a rigorous and expedited review to publish scientifically and medically significant findings in a timely manner.
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