Gold nanorods as biocompatible nano-agents for the enhanced photothermal therapy in skin disorders.

IF 2.2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Biomedical Research Pub Date : 2024-09-25 DOI:10.7555/JBR.38.20240119
Yamei Gao, Shaohu Huo, Chao Chen, Shiyu Du, Ruiyuan Xia, Jian Liu, Dandan Chen, Ziyue Diao, Xin Han, Zhiqiang Yin
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Abstract

Rod-shaped gold nanomaterials, known as gold nanorods (GNRs), may undergo specific surface alterations, because of their straightforward surface chemistry. This feature makes them appropriate for use as functional and biocompatible nano-formulations. By optimizing the absorption of longitudinally localized surface plasmon resonance (LSPR) in the near-infrared (NIR) region, which corresponds to the NIR bio-tissue window, GNRs with appropriate modifications may improve the results of photothermal treatment (PTT). In dermatology, potential noninvasive uses of GNRs to enhance wound healing, manage infections, combat cutaneous malignancies, and remodel skin tissues via PTT have attracted research attention in recent years. In this review, the basic properties of GNRs, such as shape, size, optical performance, photothermal efficiency, and metabolism, are discussed firstly. Then, the disadvantages of using these particles in photodynamic therapy (PDT) are proposed. Next, biological applications of GNRs-based PTT are summarized in detail. Finally, the limitations and future perspectives of this research are summarized, providing a comprehensive outlook for prospective GNRs with PTT.

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金纳米棒作为生物相容性纳米试剂,用于增强皮肤病的光热疗法。
被称为金纳米棒(GNRs)的棒状金纳米材料,由于其简单的表面化学性质,可发生特定的表面变化。这一特点使其适合用作功能性和生物相容性纳米制剂。通过优化纵向局部表面等离子体共振(LSPR)在近红外(NIR)区域的吸收,经过适当修饰的 GNRs 可以改善光热治疗(PTT)的效果。近年来,在皮肤科领域,GNRs 在促进伤口愈合、控制感染、抗击皮肤恶性肿瘤以及通过 PTT 重塑皮肤组织方面的潜在非侵入性用途引起了研究人员的关注。在这篇综述中,首先讨论了 GNRs 的基本特性,如形状、尺寸、光学性能、光热效率和新陈代谢。然后,提出了在光动力疗法(PDT)中使用这些颗粒的缺点。接着,详细总结了基于 GNRs 的 PTT 的生物应用。最后,总结了本研究的局限性和未来展望,为前瞻性的 GNRs 光动力疗法提供了全面的展望。
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来源期刊
Journal of Biomedical Research
Journal of Biomedical Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.60
自引率
0.00%
发文量
69
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