Sex disparities in global burden of gallbladder and biliary tract cancer: analysis of Global Burden of Disease study from 2010 to 2019.

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Gastroenterology and Hepatology Pub Date : 2024-10-08 DOI:10.1111/jgh.16763

Priyata Dutta, Pojsakorn Danpanichkul, Kanokphong Suparan, Yanfang Pang, Krittameth Rakwong, Michael R Fine, Karn Wijarnpreecha

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Abstract

Background and aim: The global burden of gallbladder and biliary tract cancer (GBTC) has been on the rise, making it a major public health concern. We aim to comprehensively analyze sex disparities in the temporal trends of GBTC incidence, mortality, and disability-adjusted life years (DALYs) regionally and globally from 2010 to 2019.

Methods: Age-standardized rates of GBTC incidence, death, and DALYs were analyzed utilizing the Global Burden of Disease study 2019.

Results: From 2010 to 2019, the estimated annual percent change (APC) of the age-standardized incidence rates (ASIRs) and age-standardized disability-adjusted life years (ASDALYs) due to GBTC globally decreased in both sexes (males, APC: -0.80%; APC: -1.00%) and (females, APC: -0.89%; APC: -0.96%). At the same time, age-standardized death rates (ASDRs) decreased only in males (APC: -0.82%) and remained stable in females. By regions, ASIRs and ASDR increased in both sexes only in Southeast Asia (SEA) but decreased in the other regions. All regions had decreased ASDALYs except for an increase in ASDALYs for females only in the SEA region (APC: 0.41%), and males have a stable trend.

Conclusions: Our study reveals substantial geographic variance in the burden of GBTC, specifically in the SEA region. Therefore, localized interventional methodologies must be undertaken to effectively address this global burden from GBTC.

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胆囊癌和胆道癌全球负担的性别差异：2010 年至 2019 年全球疾病负担研究分析。

背景和目的：胆囊癌和胆道癌（GBTC）在全球的发病率呈上升趋势，已成为一个重大的公共卫生问题。我们旨在全面分析 2010 年至 2019 年全球和地区胆囊癌发病率、死亡率和残疾调整生命年（DALYs）的时间趋势中的性别差异：方法：利用 2019 年全球疾病负担研究分析了 GBTC 发病率、死亡率和残疾调整生命年的年龄标准化比率：结果：从2010年到2019年，全球因GBTC导致的年龄标准化发病率（ASIRs）和年龄标准化残疾调整生命年（ASDALYs）的估计年百分比变化（APC）在男女两性中均有所下降（男性，APC：-0.80%；APC：-1.00%），（女性，APC：-0.89%；APC：-0.96%）。同时，只有男性的年龄标准化死亡率（ASDRs）有所下降（APC：-0.82%），女性则保持稳定。按地区划分，只有东南亚地区的男女年龄标准化死亡率和年龄标准化病死率均有所上升，其他地区均有所下降。除东南亚地区女性的 ASDALYs 有所上升（APC：0.41%）外，所有地区的 ASDALYs 均有所下降，而男性则保持稳定趋势：我们的研究揭示了 GBTC 负担的巨大地域差异，特别是在东南亚地区。因此，必须采取本地化的干预方法，才能有效解决 GBTC 带来的全球性负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastroenterology and Hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.40%

发文量

326

审稿时长

2.3 months

期刊介绍： Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.