{"title":"Neutrophils on the mast cell menu.","authors":"Eric Espinosa","doi":"10.1093/jleuko/qiae221","DOIUrl":null,"url":null,"abstract":"<p><p>A recent article in Cell reported a new peculiar interaction between mast cells (MCs) and neutrophils. Upon IgE/Ag-mediated degranulation, MCs produce leukotriene B4, which attracts migrating neutrophils. Some neutrophils are able to establish close contact with MCs and end up trapped inside the MC, forming a cell-in-cell structure. While the neutrophil eventually dies inside the vacuole, the MC benefits from the remains of its prisoner, using it as a nutrient reserve and reusing its antimicrobial weapons.</p>","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":"1217-1219"},"PeriodicalIF":3.6000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leukocyte Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jleuko/qiae221","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A recent article in Cell reported a new peculiar interaction between mast cells (MCs) and neutrophils. Upon IgE/Ag-mediated degranulation, MCs produce leukotriene B4, which attracts migrating neutrophils. Some neutrophils are able to establish close contact with MCs and end up trapped inside the MC, forming a cell-in-cell structure. While the neutrophil eventually dies inside the vacuole, the MC benefits from the remains of its prisoner, using it as a nutrient reserve and reusing its antimicrobial weapons.
最近，《细胞》（Cell）杂志上的一篇文章报道了肥大细胞与中性粒细胞之间一种新的奇特相互作用。在IgE/Ag介导的脱颗粒作用下，肥大细胞（MC）会产生白三烯B4（LTB4），从而吸引中性粒细胞迁移。一些中性粒细胞能够与肥大细胞建立密切接触，并最终被困在肥大细胞内，形成细胞间结构。嗜中性粒细胞最终会死在空泡内，而 MC 则从俘虏的残骸中获益，将其用作营养储备，并重新使用其抗菌武器。
期刊介绍：
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.
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