Prognostic value of the monocyte-to-high-density lipoprotein-cholesterol ratio in ACS patients: A systematic review and meta-analysis.

IF 3.7 3区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Kardiologia polska Pub Date : 2024-10-08 DOI:10.33963/v.phj.102773
Michał Pruc, Jacek Kubica, Maciej Banach, Damian Świeczkowski, Zubaid Rafique, William Frank Peacock, Zbigniew Siudak, Stanisław Surma, Prabath Nanayakkara, Krzysztof Kurek, Anne Lepetit, Łukasz Szarpak
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Abstract

Background: Globally, diseases of the cardiovascular system stand as the principal contributors to mortality and are anticipated to show an upward trajectory. The occurrence of Acute Coronary Syndrome (ACS) has been linked to underlying inflammatory processes. The monocyte-to-high-density lipoprotein-cholesterol (MHR) ratio has garnered significant attention as a prognostic biomarker, encapsulating the synergistic roles of inflammation and lipid metabolism in the pathophysiology of cardiovascular diseases, including ACS.

Aims: This meta-analysis examines the prognostic MHR ratio in ACS patients.

Methods: We systematically searched PubMed, Embase, Scopus, Web of Science, and the Cochrane Library databases to identify the relevant meta-analyses up to February 26, 2024. The findings were aggregated into risk ratios with 95% confidence intervals.

Results: Eleven studies, with 7421 patients, were included. Low MHR levels compared to high MHR levels were associated with statistically significantly lower in-hospital mortality (0.9% vs. 5.5%; respectively; p<0.001), 3-month mortality (4.4% vs. 11.2%; p = 0.02), 6-month follow-up mortality (4.0% vs. 10.2%; p = 0.03), 1-year mortality (4.2%, vs. 10.2%; p<0.001), as well as long-term follow-up mortality (7.5% vs. 13.7%; p<0.001).

Conclusions: MHR has both good predictive properties for mortality and MACE (short- and long-term). Data indicate that MHR may improve in-hospital and long-term cardiovascular risk prediction. It may, therefore, be an effective tool for risk re-estimation and the selection of patients for whom intensive lipid-lowering treatment may be particularly useful.

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ACS 患者单核细胞与高密度脂蛋白胆固醇比值的预后价值:系统回顾和荟萃分析。
背景:在全球范围内,心血管系统疾病是导致死亡的主要因素,而且预计还会呈上升趋势。急性冠状动脉综合征(ACS)的发生与潜在的炎症过程有关。单核细胞与高密度脂蛋白胆固醇(MHR)比值作为一种预后生物标志物备受关注,它体现了炎症和脂质代谢在心血管疾病(包括 ACS)病理生理学中的协同作用:我们系统地检索了 PubMed、Embase、Scopus、Web of Science 和 Cochrane Library 数据库,以确定截至 2024 年 2 月 26 日的相关荟萃分析。研究结果汇总为风险比和95%置信区间:结果:共纳入 11 项研究,7421 名患者。低MHR水平与高MHR水平相比,院内死亡率在统计学上明显降低(分别为0.9% vs. 5.5%;p结论:低MHR水平与高MHR水平相比,院内死亡率在统计学上明显降低(分别为0.9% vs. 5.5%;p):MHR对死亡率和MACE(短期和长期)均有良好的预测作用。数据表明,MHR 可以改善院内和长期心血管风险预测。因此,它可能是一种有效的工具,用于风险再估计和选择强化降脂治疗可能特别有用的患者。
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来源期刊
Kardiologia polska
Kardiologia polska 医学-心血管系统
CiteScore
3.00
自引率
24.20%
发文量
431
审稿时长
3-6 weeks
期刊介绍: Kardiologia Polska (Kardiol Pol, Polish Heart Journal) is the official peer-reviewed journal of the Polish Cardiac Society (PTK, Polskie Towarzystwo Kardiologiczne) published monthly since 1957. It aims to provide a platform for sharing knowledge in cardiology, from basic science to translational and clinical research on cardiovascular diseases.
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