NRG1 Fusions in NSCLC: Being eNRGy Conscious.

IF 5.1 Q1 ONCOLOGY Lung Cancer: Targets and Therapy Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI:10.2147/LCTT.S464626
Brinda Gupta, Laura Gosa Barrett, Stephen V Liu
{"title":"NRG1 Fusions in NSCLC: Being eNRGy Conscious.","authors":"Brinda Gupta, Laura Gosa Barrett, Stephen V Liu","doi":"10.2147/LCTT.S464626","DOIUrl":null,"url":null,"abstract":"<p><p>Fusions in neuregulin 1 (<i>NRG1</i>) are rare oncogenic drivers that occur across a number of tumor types, including non-small cell lung cancer (NSCLC). <i>NRG1</i> has an EGF-like domain that serves as a ligand for HER3 receptors, inducing heterodimerization, usually with HER2, and subsequent activation of oncogenic downstream signaling pathways. Emerging evidence suggests that NSCLC harboring <i>NRG1</i> fusions do not respond as well to standard therapeutic options including chemotherapy and immunotherapy, and prognosis is poor. Novel treatment approaches targeting the HER2/HER3 pathway are under investigation. Here, we discuss the biology and detection of <i>NRG1</i> fusions in NSCLC and promising targeted treatment strategies for tumors harboring the mutation.</p>","PeriodicalId":18066,"journal":{"name":"Lung Cancer: Targets and Therapy","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457762/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung Cancer: Targets and Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/LCTT.S464626","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Fusions in neuregulin 1 (NRG1) are rare oncogenic drivers that occur across a number of tumor types, including non-small cell lung cancer (NSCLC). NRG1 has an EGF-like domain that serves as a ligand for HER3 receptors, inducing heterodimerization, usually with HER2, and subsequent activation of oncogenic downstream signaling pathways. Emerging evidence suggests that NSCLC harboring NRG1 fusions do not respond as well to standard therapeutic options including chemotherapy and immunotherapy, and prognosis is poor. Novel treatment approaches targeting the HER2/HER3 pathway are under investigation. Here, we discuss the biology and detection of NRG1 fusions in NSCLC and promising targeted treatment strategies for tumors harboring the mutation.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
NSCLC 中的 NRG1 融合:要有 eNRGy 意识。
神经胶质蛋白 1(NRG1)融合是一种罕见的致癌驱动因素,可发生在多种肿瘤类型中,包括非小细胞肺癌(NSCLC)。NRG1 有一个类似 EGF 的结构域,可作为 HER3 受体的配体,诱导异源二聚体(通常与 HER2 一起),并随后激活致癌的下游信号通路。新的证据表明,携带 NRG1 融合的 NSCLC 对化疗和免疫疗法等标准治疗方案的反应不佳,预后较差。目前正在研究针对HER2/HER3通路的新型治疗方法。在此,我们将讨论NSCLC中NRG1融合的生物学特性和检测方法,以及针对携带这种突变的肿瘤的有希望的靶向治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
8.10
自引率
0.00%
发文量
10
审稿时长
16 weeks
期刊最新文献
Real-World Outcomes with Lurbinectedin in Second Line and Beyond for Extensive Stage Small Cell Lung Cancer in Korea. Adagrasib in KRYSTAL-12 has Broken the KRAS G12C Enigma Code in Non-Small Cell Lung Carcinoma. NRG1 Fusions in NSCLC: Being eNRGy Conscious. Pulmonary Spindle Cell Carcinoma Mimicking Granulomatous Inflammation: A Rare Case Report and Brief Review of the Literature. Redefining Recovery: The Transformative Impact of the ALINA Trial on Adjuvant Therapy for ALK-Positive Non-Small Cell Lung Cancer.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1