NRG1 Fusions in NSCLC: Being eNRGy Conscious.

IF 5.1 Q1 ONCOLOGY Lung Cancer: Targets and Therapy Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI:10.2147/LCTT.S464626
Brinda Gupta, Laura Gosa Barrett, Stephen V Liu
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Abstract

Fusions in neuregulin 1 (NRG1) are rare oncogenic drivers that occur across a number of tumor types, including non-small cell lung cancer (NSCLC). NRG1 has an EGF-like domain that serves as a ligand for HER3 receptors, inducing heterodimerization, usually with HER2, and subsequent activation of oncogenic downstream signaling pathways. Emerging evidence suggests that NSCLC harboring NRG1 fusions do not respond as well to standard therapeutic options including chemotherapy and immunotherapy, and prognosis is poor. Novel treatment approaches targeting the HER2/HER3 pathway are under investigation. Here, we discuss the biology and detection of NRG1 fusions in NSCLC and promising targeted treatment strategies for tumors harboring the mutation.

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NSCLC 中的 NRG1 融合:要有 eNRGy 意识。
神经胶质蛋白 1(NRG1)融合是一种罕见的致癌驱动因素,可发生在多种肿瘤类型中,包括非小细胞肺癌(NSCLC)。NRG1 有一个类似 EGF 的结构域,可作为 HER3 受体的配体,诱导异源二聚体(通常与 HER2 一起),并随后激活致癌的下游信号通路。新的证据表明,携带 NRG1 融合的 NSCLC 对化疗和免疫疗法等标准治疗方案的反应不佳,预后较差。目前正在研究针对HER2/HER3通路的新型治疗方法。在此,我们将讨论NSCLC中NRG1融合的生物学特性和检测方法,以及针对携带这种突变的肿瘤的有希望的靶向治疗策略。
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来源期刊
CiteScore
8.10
自引率
0.00%
发文量
10
审稿时长
16 weeks
期刊最新文献
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