Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings.

IF 3.3 3区 医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-10-04 DOI:10.2174/0113895575331878240924035332
Bhagavathi Sundaram Sivamaruthi, Natarajan Sisubalan, Shucai Wang, Periyanaina Kesika, Chaiyavat Chaiyasut
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Abstract

Green tea (GT) is rich in Phyto-active compounds such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC), catechin, and tannic acid, which exhibit synergistic effects when combined. Preclinical studies demonstrate that GT and its compounds can reduce reactive oxygen species (ROS), enhance antioxidant capacity, and alleviate aging-related issues such as memory impairments, cognitive decline, and shortened lifespan. Clinical trials corroborate the efficacy of topical GT formulations in improving skin tone, texture, and elasticity and reducing wrinkles. The present manuscript summarizes the recent update on the anti-aging potential of GT and its possible mechanisms. The literature survey suggested that GT consumption is linked to improved cognition, reduced depression levels, and activation of pathways in model organisms like C. elegans. Additionally, tea polyphenols enhance fibroblast mitophagy, boost hippocampal synaptic plasticity in rodents, and mitigate age-related cognitive decline. Moreover, EGCG exhibits anti-aging properties by reducing TNF-induced MMP-1 expression, suppressing ERK signaling, and inhibiting MEK and Src phosphorylation in human dermal fibroblasts. In the context of skin permeation and deposition, optimized transpersonal formulation (TF) incorporating EGCG and hyaluronic acid (HA) demonstrated significantly increased skin permeation and deposition of EGCG compared to plain EGCG. Furthermore, EGCG protects cardiomyocytes via the PPARγ pathway and combats age-related muscle loss through miRNA-486-5p regulation, AKT activation, and FoxO1a-mediated expression of MuRF1 and Atrogin-1. In conclusion, the regular consumption of GT holds promise for promoting physical and mental health, delaying brain and skin aging, and improving overall health by enhancing total antioxidant capacity.

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探索绿茶(Camellia sinensis L.)在抗衰老方面的治疗潜力:机制和研究结果的全面回顾。
绿茶(GT)富含表没食子儿茶素没食子酸酯(EGCG)、表没食子儿茶素(EGC)、表儿茶素没食子酸酯(ECG)、表儿茶素(EC)、儿茶素和单宁酸等植物活性化合物,这些化合物结合在一起会产生协同效应。临床前研究表明,GT 及其化合物可以减少活性氧(ROS),提高抗氧化能力,缓解与衰老有关的问题,如记忆力减退、认知能力下降和寿命缩短。临床试验证实,GT 外用制剂在改善肤色、质地和弹性以及减少皱纹方面具有功效。本手稿总结了 GT 抗衰老潜力及其可能机制的最新进展。文献调查表明,饮用 GT 与改善认知、降低抑郁水平以及激活模式生物(如秀丽隐杆线虫)的通路有关。此外,茶多酚还能增强成纤维细胞的有丝分裂,提高啮齿类动物海马突触的可塑性,缓解与年龄相关的认知能力衰退。此外,EGCG 还能减少 TNF 诱导的 MMP-1 表达,抑制 ERK 信号传导,抑制人真皮成纤维细胞中 MEK 和 Src 的磷酸化,从而具有抗衰老特性。在皮肤渗透和沉积方面,与普通EGCG相比,含有EGCG和透明质酸(HA)的优化换位配方(TF)显著提高了EGCG的皮肤渗透和沉积能力。此外,EGCG还能通过PPARγ途径保护心肌细胞,并通过miRNA-486-5p调控、AKT激活以及FoxO1a介导的MuRF1和Atrogin-1的表达来对抗与年龄相关的肌肉流失。总之,经常食用 GT 有助于促进身心健康、延缓大脑和皮肤衰老,并通过提高总抗氧化能力改善整体健康。
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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
231
审稿时长
6 months
期刊介绍: The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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