Musculoskeletal involvement in systemic sclerosis.

IF 1.4 Q3 RHEUMATOLOGY Reumatologia Pub Date : 2024-01-01 Epub Date: 2024-08-18 DOI:10.5114/reum/190576
Ewa Wielosz, Marcin Grzegorz Hyła
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Abstract

Systemic sclerosis (SSc) is a multi-organ, systemic connective tissue disease, which affects the lungs, heart, gastrointestinal tract, kidneys, skin, and musculoskeletal system. Musculoskeletal involvement is observed in 40-90% of patients with SSc. During the disease, any structure of the musculoskeletal system, such as bones, joints, tendon sheaths, tendons, and muscles, may be affected. The most common symptoms include joint pain, arthritis, tendinitis leading to tendon rupture, acro-osteolysis, calcinosis, myalgia, and myositis. Osteo-articular complications and changes in the soft tissues of the hand lead to finger contracture, which causes deterioration of the patients' quality of life and disability. To sum up, a more detailed understanding of the aetiology leading to progressive changes in the musculoskeletal system may contribute to the introduction of new therapeutic options, and thus improve the quality of life and reduce disability in patients with SSc.

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系统性硬化症的肌肉骨骼受累。
系统性硬化症(SSc)是一种多器官、全身性结缔组织疾病,会影响肺、心脏、胃肠道、肾脏、皮肤和肌肉骨骼系统。40%-90%的 SSc 患者会出现肌肉骨骼受累。患病期间,骨骼、关节、腱鞘、肌腱和肌肉等肌肉骨骼系统的任何结构都可能受到影响。最常见的症状包括关节疼痛、关节炎、导致肌腱断裂的肌腱炎、关节骨溶解、钙化、肌痛和肌炎。骨关节并发症和手部软组织的变化会导致手指挛缩,从而导致患者生活质量下降和残疾。总之,更详细地了解导致肌肉骨骼系统渐进性变化的病因,可能有助于引入新的治疗方案,从而改善 SSc 患者的生活质量并减少残疾。
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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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