Symptom clusters and symptom network analysis during immunotherapy in lung cancer patients.

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES Supportive Care in Cancer Pub Date : 2024-10-09 DOI:10.1007/s00520-024-08918-0

Xuying Yang, Jingcui Bai, Ruili Liu, Xiaoping Wang, Gongyu Zhang, Xuehua Zhu

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Abstract

Objective: This study analyzes symptoms in lung cancer patients undergoing immunotherapy to identify core symptom clusters through network analysis and lay a foundation for effective symptom management programs.

Methods: The sample comprised 240 lung cancer patients receiving immunotherapy. Participants were assessed using the Memorial Symptom Assessment Scale. Exploratory factor analysis was used to extract symptom clusters, and network analysis using JASP 0.17.3 was performed to explore the centrality indices and density of the symptom network.

Results: Five symptom clusters were identified, i.e., emotion-related, lung cancer-related, physical, skin, and neural symptom clusters, with a cumulative variance contribution rate of 55.819%. Network analysis revealed that sadness was the most intense symptom (r_s = 2.189), dizziness was the most central symptom (r_c = 1.388), and fatigue was the most significant bridging symptom (r_b = 2.575).

Conclusion: This study identified five symptom clusters and a symptom network among lung cancer patients during immunotherapy. The network analysis's centrality indices and network density results can assist healthcare professionals in devising more precise symptom management strategies.

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肺癌患者接受免疫疗法期间的症状群和症状网络分析。

目的：本研究分析了接受免疫治疗的肺癌患者的症状，通过网络分析确定核心症状群，为有效的症状管理方案奠定基础：本研究对接受免疫治疗的肺癌患者的症状进行分析，通过网络分析确定核心症状群，为有效的症状管理计划奠定基础：样本包括240名接受免疫治疗的肺癌患者。方法：样本包括240名接受免疫治疗的肺癌患者，采用纪念症状评估量表对参与者进行评估。采用探索性因子分析提取症状群，并使用 JASP 0.17.3 进行网络分析，以探索症状网络的中心性指数和密度：结果：共发现五个症状群，即情绪相关症状群、肺癌相关症状群、身体相关症状群、皮肤相关症状群和神经相关症状群，累计方差贡献率为 55.819%。网络分析显示，悲伤是最强烈的症状（rs = 2.189），头晕是最核心的症状（rc = 1.388），疲劳是最显著的桥接症状（rb = 2.575）：本研究发现了肺癌患者在免疫治疗期间的五个症状群和一个症状网络。网络分析的中心性指数和网络密度结果可帮助医护人员制定更精确的症状管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.