Utility of a synthetic hybrid-scale fiber matrix in the management of pyoderma gangrenosum: a case study.

IF 1.4 4区医学 Q3 DERMATOLOGY Wounds : a compendium of clinical research and practice Pub Date : 2024-09-01

Kaitlyn J Loesel, Blake E Pritchett, Alexander Schultz, Jonathan M Towarnicki

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Abstract

Background: Pyoderma gangrenosum (PG) is a rare skin condition that is challenging for both patients and physicians alike. It is extremely painful and can become debilitating for many patients. PG has a mortality rate of 16% at 8 years, and patients with PG have a threefold risk of death compared to the general population. Currently, the management of PG is not standardized and is somewhat experimental as these wounds are prone to pathergy.

Case report: A single patient diagnosed with PG of both lower extremities was successfully treated with a protocol that included serial wound debridement with a sterile scrub brush and hydrodebridement followed by application of a synthetic hybrid-scale fiber matrix (SHSFM) dressing. The patient's wounds successfully healed and the resolution was maintained at 2 years, at which time the patient was discharged from the clinic.

Conclusion: To the authors' knowledge, this is the first study reporting the use of SHSFM as a primary treatment option for PG.

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合成杂化纤维基质在治疗脓皮病中的应用：一项案例研究。

背景：坏疽性脓皮病（PG）是一种罕见的皮肤病，对患者和医生来说都是一种挑战。脓皮病给患者带来极大的痛苦，并可能使许多患者变得虚弱不堪。脓皮病患者 8 年的死亡率为 16%，与普通人相比，脓皮病患者的死亡风险是普通人的三倍。目前，PG 的治疗方法还没有标准化，而且由于这些伤口容易发生脓肿，所以治疗方法还处于试验阶段：病例报告：一名被诊断为双下肢 PG 的患者成功接受了治疗，治疗方案包括使用无菌刷子和水力清创器对伤口进行连续清创，然后使用合成杂化纤维基质（SHSFM）敷料。患者的伤口成功愈合，伤口愈合情况维持了两年，患者于两年后出院：据作者所知，这是第一项报道使用 SHSFM 作为 PG 主要治疗方案的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.