Fecal microbiota and metabolites in the pathogenesis and precision medicine for inflammatory bowel disease.

IF 5.1 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Precision Clinical Medicine Pub Date : 2024-09-23 eCollection Date: 2024-09-01 DOI:10.1093/pcmedi/pbae023
Long Ju, Zhimin Suo, Jian Lin, Zhanju Liu
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Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, and its pathogenesis is believed to be associated with an imbalance between commensal organisms and the intestinal immune system. This imbalance is significantly influenced by the intestinal microbiota and metabolites and plays a critical role in maintaining intestinal mucosal homeostasis. However, disturbances in the intestinal microbiota cause dysregulated immune responses and consequently induce intestinal inflammation. Recent studies have illustrated the roles of the intestinal microbiota in the pathogenesis of IBD and underscored the potential of precision diagnosis and therapy. This work summarises recent progress in this field and particularly focuses on the application of the intestinal microbiota and metabolites in the precision diagnosis, prognosis assessment, treatment effectiveness evaluation, and therapeutic management of IBD.

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炎症性肠病发病机制和精准医疗中的粪便微生物群和代谢物。
炎症性肠病(IBD)是一种胃肠道慢性炎症性疾病,其发病机制被认为与共生生物和肠道免疫系统之间的失衡有关。这种失衡在很大程度上受到肠道微生物群和代谢产物的影响,并在维持肠道粘膜稳态方面发挥着关键作用。然而,肠道微生物群的紊乱会导致免疫反应失调,进而诱发肠道炎症。最近的研究表明了肠道微生物群在 IBD 发病机制中的作用,并强调了精准诊断和治疗的潜力。本研究总结了这一领域的最新进展,尤其关注肠道微生物群和代谢物在 IBD 的精准诊断、预后评估、疗效评价和治疗管理中的应用。
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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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