Structure, biosynthesis and activity of indolactam alkaloids.

Q1 Biochemistry, Genetics and Molecular Biology Alkaloids: Chemistry and Biology Pub Date : 2024-01-01 Epub Date: 2024-08-12 DOI:10.1016/bs.alkal.2024.07.001
Leanne A Pearson, Peter Karuso, Brett A Neilan
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Abstract

Indolactam alkaloids are a family of aromatic toxins produced by various actinobacteria and the cyanobacterium, Moorena producens. The best characterized examples include the teleocidins, lyngbyatoxins, olivoretins, blastmycetins, and pendolmycins, which share a nine-membered lactam core, comprised from l-tryptophanol and l-valine. Contact with indolactam alkaloids has been linked to severe dermatitis (swimmers itch), while accidental ingestion may lead to illness and fatalities. Indolactam alkaloids are also potent tumor promotors, due to their activation of protein kinase C isozymes. This chapter reviews the current literature on indolactam alkaloids, from their discovery in the early 1960s up to 2024. Topics covered include the isolation, structural elucidation, biosynthesis, bioactivity, and total synthesis of the indolactam alkaloid core.

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吲哚内酰胺生物碱的结构、生物合成和活性。
吲哚内酰胺生物碱是一系列芳香族毒素,由各种放线菌和蓝藻(Moorena producens)产生。最典型的例子包括 teleocidins、lyngbyatoxins、olivoretins、blastmycetins 和 pendolmycins,它们都有一个由 l-色氨酸和 l-缬氨酸组成的九元内酰胺核心。接触吲哚内酰胺生物碱会引发严重的皮炎(游泳者瘙痒症),而意外摄入则可能导致疾病和死亡。由于吲哚内酰胺生物碱能激活蛋白激酶 C 同工酶,因此也是一种有效的肿瘤促进剂。本章回顾了从 20 世纪 60 年代初发现吲哚内酰胺生物碱到 2024 年有关吲哚内酰胺生物碱的现有文献。主题包括吲哚内酰胺生物碱核心的分离、结构阐明、生物合成、生物活性和全合成。
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来源期刊
Alkaloids: Chemistry and Biology
Alkaloids: Chemistry and Biology Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
13.70
自引率
0.00%
发文量
21
期刊最新文献
Preface. Structural variety and pharmacological potential of naphthylisoquinoline alkaloids. Structure, biosynthesis and activity of indolactam alkaloids. The synthetic chemistry of sarpagine-ajmaline-type alkaloids. Dedication
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