Choroid Plexus Pathophysiology.

Ya'el Courtney, Alexandra Hochstetler, Maria K Lehtinen
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Abstract

This review examines the crucial roles of the choroid plexus (ChP) in central nervous system (CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic potential. Structural changes in the human ChP have been reported across various diseases in case reports and descriptive work, but studies have yet to pin down the physiological relevance of these changes. We highlight primary pathologies of the ChP, as well as their significance in neurologic disorders, including stroke, hydrocephalus, infectious diseases, and neurodegeneration. Synthesizing recent research, this review positions the ChP as a critical player in CNS homeostasis and pathology, advocating for enhanced focus on its mechanisms to unlock new diagnostic and treatment strategies and ultimately improve patient outcomes in CNS diseases. Whether acting as a principal driver of disease, a gateway for pathogens into the CNS, or an orchestrator of neuroimmune processes, the ChP holds tremendous promise as a therapeutic target to attenuate a multitude of CNS conditions.

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脉络丛病理生理学
这篇综述探讨了脉络丛(ChP)在中枢神经系统(CNS)病理学中的关键作用,强调了脉络丛在疾病机制和治疗潜力中的参与。在病例报告和描述性工作中,人类脉络丛的结构变化已在各种疾病中有所报道,但研究尚未明确这些变化的生理相关性。我们重点介绍了 ChP 的主要病理变化及其在神经系统疾病(包括中风、脑积水、感染性疾病和神经变性)中的重要性。综合近期的研究,本综述将胆碱酯酶定位为中枢神经系统稳态和病理学中的关键角色,主张加强对胆碱酯酶机制的关注,以开启新的诊断和治疗策略,最终改善中枢神经系统疾病患者的预后。无论是作为疾病的主要驱动因素、病原体进入中枢神经系统的通道,还是神经免疫过程的协调者,胆碱酯酶都有望成为减轻多种中枢神经系统疾病的治疗靶点。
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来源期刊
CiteScore
62.60
自引率
0.00%
发文量
40
期刊介绍: The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.
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