Protective effect of Zhizi Huangqi Shanzha formula on aflatoxin poisoning in mice and its effect on intestinal flora.

Sun Chuanbo, X U Guangpei, Jiang Ping, Huang Shipping, Chen Cunwu, H E Yanfei
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Abstract

Objective: To evaluate the protective effect of Zhizi Huangqi Shanzha formula (, ZHSF) on aflatoxin-induced liver injury.

Methods: The protective effect of ZHSF on the aflatoxin-induced liver injury was evaluated by histological observation, blood cell analysis, evaluation of liver function and immunity, and gut microbiota analysis.

Results: ZHSF can significantly up-regulate the percentage of lymphocytes and eosinophils in the blood of Aflatoxin B1-intoxicated mice, down-regulate the levels of serum aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, and recover the liver tissue structure. Aflatoxin poisoning induces a variation of the intestinal flora of mice, and ZHSF may recover the variation of intestinal flora induced by Aflatoxin B1. Cluster analysis showed that the intestinal flora of mice in the intervention group was more similar to that of the control group. Correlation analysis showed that Lachnospiraceae, Desulfovibrio, and Lactobacillus may be the key flora for the pharmacological effects of ZHSF.

Conclusions: ZHSF may protect against aflatoxin-induced liver damage, improve immunity, and inhibit oxidative stress by regulating the composition and relative abundance of intestinal flora, which makes it a promising liver-protective candidate drug.

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枳实黄芪山楂方对小鼠黄曲霉毒素中毒的保护作用及其对肠道菌群的影响
目的:评估枳实黄芪山楂方对黄曲霉毒素所致肝损伤的保护作用:评估枳实黄芪山楂方(ZHSF)对黄曲霉毒素所致肝损伤的保护作用:方法:通过组织学观察、血细胞分析、肝功能和免疫功能评估以及肠道微生物群分析,评价枳实黄芪山楂方对黄曲霉毒素所致肝损伤的保护作用:结果:ZHSF能明显提高黄曲霉毒素B1中毒小鼠血液中淋巴细胞和嗜酸性粒细胞的比例,降低血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶和丙二醛的水平,恢复肝脏组织结构。黄曲霉毒素中毒会引起小鼠肠道菌群失调,而 ZHSF 可以恢复黄曲霉毒素 B1 引起的肠道菌群失调。聚类分析显示,干预组小鼠的肠道菌群与对照组更为相似。相关分析表明,Lachnospiraceae、Desulfovibrio和Lactobacillus可能是ZHSF药理作用的关键菌群:结论:ZHSF可通过调节肠道菌群的组成和相对丰度来防止黄曲霉毒素引起的肝损伤、提高免疫力和抑制氧化应激,因此是一种很有前景的保肝候选药物。
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