Relationship between septic acute kidney injury and adiponectin: A retrospective study in patients undergoing continuous plasma exchange with dialysis.
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Abstract
Introduction: Adiponectin (APN) is a multimeric protein with anti-inflammatory properties that is specifically secreted by adipocytes. Continuous plasma exchange with dialysis (cPED) is a blood purification therapy in which plasma exchange is performed using a selective membrane plasma separator while the dialysate flows outside the hollow fibers.
Methods: Patients with sepsis were divided into two groups based on the presence or absence of acute kidney injury (AKI) complications: AKI and non-AKI group.
Results: Plasma APN levels significantly increased after cPED in both groups. The creatinine levels in the AKI group before cPED were significantly higher than those in the non- AKI group. The plasma APN levels in the AKI group before cPED were significantly higher than those in the non-AKI group.
Conclusion: cPED increased APN levels in both patients with and without AKI. Therefore, cPED therapy may be a promising intervention for increasing APN levels in patients with sepsis.
简介脂联素（APN）是一种具有抗炎特性的多聚蛋白，专门由脂肪细胞分泌。连续血浆置换透析（cPED）是一种血液净化疗法，使用选择性膜血浆分离器进行血浆置换，同时透析液在中空纤维外流动：根据有无急性肾损伤（AKI）并发症将败血症患者分为两组：结果：血浆 APN 水平明显升高：结果：两组患者 cPED 后血浆 APN 水平均明显升高。cPED 前 AKI 组的肌酐水平明显高于非 AKI 组。结论：cPED 可增加 AKI 和非 AKI 患者的 APN 水平。因此，cPED疗法可能是提高脓毒症患者APN水平的一种有前途的干预措施。
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