Prognostic value of myositis-specific antibodies in patients with idiopathic interstitial pneumonia.

IF 2.6 3区医学 Q2 RESPIRATORY SYSTEM BMC Pulmonary Medicine Pub Date : 2024-10-10 DOI:10.1186/s12890-024-03326-w

Hiroki Wakabayashi, Kotaro Iwasaki, Yu Murakami, Kenta Takashima, Kaichi Kaneko, Yasuo Matsuzawa

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Abstract

Background: Patients with idiopathic interstitial pneumonia (IIP) often exhibit positivity for myositis-specific antibodies (MSA). However, the significance of this finding remains unclear. In this study, we investigated the association of MSA with the prognosis and risk of acute exacerbation in patients with IIP.

Methods: We retrospectively reviewed the medical records of patients with IIP and examined the effect of each MSA subtype on survival and acute exacerbation.

Results: Of 240 patients with IIP, 48 (20%) exhibited positivity for MSA. The MSA subtypes included: PL-7 (antithreonyl; n = 16, 6.7%); signal recognition particle (n = 13, 5.4%); PL-12 (antialanyl; n = 9, 3.8%); Mi-2 (n = 8, 3.3%); OJ (anti-isoleucyl; n = 7, 2.9%). During the 382 days (382 ± 281 days) of observation, 32 (13%) patients expired, and 27 (11%) experienced an acute exacerbation. Cox proportional hazards regression analysis demonstrated that age at the initial visit (hazard ratio [HR]: 1.072; 95% confidence interval [CI]: 1.017-1.131; P = 0.01), PL-7 (HR: 4.785; 95% CI: 1.528-14.925; P = 0.007), and PL-12 (HR: 3.922; 95% CI: 1.198-12.82; P = 0.024) were independent predictors of survival time. PL-7 (HR: 3.268; 95% CI: 1.064-10; P = 0.039) and PL-12 (HR: 5.747; 95% CI: 1.894-7.544; P = 0.002) were independent predictors of time from first visit to acute exacerbation.

Conclusion: Detecting MSA in patients with interstitial lung disease may be useful in predicting prognosis and providing a rationale for intensive treatment.

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特发性间质性肺炎患者肌炎特异性抗体的预后价值。

背景：特发性间质性肺炎（IIP）患者常表现出肌炎特异性抗体（MSA）阳性。然而，这一发现的意义仍不明确。在这项研究中，我们调查了 MSA 与特发性间质性肺炎患者的预后和急性加重风险之间的关系：我们回顾性地查看了 IIP 患者的病历，并研究了每种 MSA 亚型对生存期和急性加重的影响：在 240 例 IIP 患者中，48 例（20%）显示 MSA 阳性。MSA亚型包括PL-7（抗苏氨酰；n = 16，6.7%）；信号识别颗粒（n = 13，5.4%）；PL-12（抗丙氨酰；n = 9，3.8%）；Mi-2（n = 8，3.3%）；OJ（抗异亮氨酰；n = 7，2.9%）。在382天（382±281天）的观察期间，32名（13%）患者死亡，27名（11%）患者病情急性加重。1.072；95% 置信区间 [CI]：1.017-1.131；P = 0.01）、PL-7（HR：4.785；95% CI：1.528-14.925；P = 0.007）和 PL-12（HR：3.922；95% CI：1.198-12.82；P = 0.024）是生存时间的独立预测因素。PL-7（HR：3.268；95% CI：1.064-10；P = 0.039）和PL-12（HR：5.747；95% CI：1.894-7.544；P = 0.002）是首次就诊至急性加重时间的独立预测因子：结论：检测间质性肺病患者的 MSA 可能有助于预测预后，并为强化治疗提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.