Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2024-10-10 DOI:10.2174/0109298673325229240928040758

Manuele Figueiredo da Silva, Arestides Alves Lins, Midiane Correia Gomes, Washley Phyama de Jesus Marinho, Rodrigo Santos Aquino de Araújo, Ricardo Olimpio de Moura, Peng Zhan, Igor José Dos Santos Nascimento, Edeildo Ferreira da Silva-Júnior

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Abstract

The term cancer is used to describe a complex pathology characterized by the uncontrollable proliferation of cells, which displays a fast metastatic spread, being a disease with difficult treatment. In this context, Phosphatidylinositol 3-kinase (PI3K) represents a promising pathway to be inhibited, aiming to develop anticancer agents, since it performs a pivotal role in regulating essential cellular processes, including cell proliferation, growth, autophagy, and apoptosis. In parallel, natural compounds can effectively represent a therapeutic strategy to fight against malignant cells. Then, compounds derived from various plant sources, such as flavonoids, terpenoids, alkaloids, coumarins, and lignans, have exhibited remarkable in vitro and in vivo anticancer properties. This review focused in the exploration of natural products targeting the PI3K/AKT/m-TOR signaling pathway, demonstrating that these compounds could even further investigated to reveal novel and effective anticancer drugs in the future.

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从靶向 PI3K/AKT/mTOR 信号通路的天然化合物中发现抗癌药物。

癌症是一种复杂的病理现象，其特点是细胞无法控制地增殖，并迅速转移扩散，是一种难以治疗的疾病。在这种情况下，磷脂酰肌醇 3- 激酶（PI3K）是一种有希望被抑制的途径，旨在开发抗癌药物，因为它在调节细胞增殖、生长、自噬和凋亡等重要细胞过程中发挥着关键作用。与此同时，天然化合物可以有效地代表一种对抗恶性细胞的治疗策略。从各种植物中提取的化合物，如黄酮类、萜类、生物碱、香豆素和木脂素等，在体外和体内均表现出显著的抗癌特性。这篇综述重点探讨了以 PI3K/AKT/m-TOR 信号通路为靶点的天然产物，表明这些化合物甚至可以在未来进一步研究，以揭示新型有效的抗癌药物。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.