Real-world trends in acute viral hepatitis in Japan: A nationwide questionnaire-based survey.

IF 3.9 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Hepatology Research Pub Date : 2024-10-10 DOI:10.1111/hepr.14123

Kazuya Okushin, Tatsuya Kanto, Masaaki Korenaga, Kazuhiko Ikeuchi, Toshiyuki Kishida, Akira Kado, Mitsuhiro Fujishiro, Takeya Tsutsumi, Tomoyuki Takura, Hiroshi Yotsuyanagi

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Abstract

Aim: The actual incidence of acute viral hepatitis in Japan remains unclear. We aimed to investigate trends in the incidence of acute hepatitis B and C infections in Japan.

Methods: A nationwide, multicenter, retrospective questionnaire-based survey was conducted. Participating hospitals received questionnaires through nationwide geographically distributed regional core centers certified as specialists in hepatitis treatment. The questionnaire included hospital size and the number of patients diagnosed with acute hepatitis B or C during each fiscal year (FY) from 2015 to 2022. The sex distribution in each FY was also documented. Comparisons were made before and during the COVID-19 era (2015-2019 vs. 2020-2022), and between populous and non-populous prefectures.

Results: Responses to the questionnaires were obtained from 127 institutions in 29 prefectures covering eight regions in Japan. A median of 127.0 patients with acute hepatitis B (interquartile range [IQR] 106.5-131.8 patients) were reported during each FY, and the incidence significantly decreased during the fiscal years 2020-2022 compared with the fiscal years 2015-2020 (median 96.0 [IQR 91.0-103.0] patients vs. 131.0 [IQR 128.0-134.0] patients; p = 0.03). A median of 10.0 (IQR, 7.8-13.5) patients were reported with acute hepatitis C during each FY. The proportions of men in acute hepatitis B and C were significantly higher in populous prefectures.

Conclusions: Populous prefectures had a higher proportion of men among viral hepatitis patients than non-populous prefectures. Estimating the high-risk populations in each area could provide insights to advance the elimination of viral hepatitis.

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日本急性病毒性肝炎的现实趋势：全国范围内的问卷调查。

目的：日本急性病毒性肝炎的实际发病率仍不清楚。我们旨在调查日本急性乙型和丙型肝炎感染率的变化趋势：方法：我们在全国范围内开展了一项多中心回顾性问卷调查。参与调查的医院通过在全国范围内按地域分布的经认证的肝炎治疗专家区域核心中心接收问卷。问卷内容包括医院规模以及 2015 年至 2022 年每个财政年度（FY）确诊的急性乙型或丙型肝炎患者人数。每个财政年度的性别分布情况也被记录在案。在 COVID-19 时代（2015-2019 年与 2020-2022 年）之前和期间进行了比较，并在人口众多的都道府县和非人口众多的都道府县之间进行了比较：日本 8 个地区 29 个都道府县的 127 家机构对调查问卷进行了回复。每个财政年度报告的急性乙型肝炎患者中位数为 127.0 人（四分位数间距 [IQR] 106.5-131.8 人），与 2015-2020 财政年度相比，2020-2022 财政年度的发病率显著下降（中位数 96.0 [IQR 91.0-103.0] 人 vs. 131.0 [IQR 128.0-134.0] 人；p = 0.03）。每个财政年度报告的急性丙型肝炎患者中位数为 10.0（IQR，7.8-13.5）人。在人口众多的都道府县，急性乙型和丙型肝炎患者中男性的比例明显更高：结论：与非人口大县相比，人口大县的病毒性肝炎患者中男性比例更高。对每个地区的高危人群进行估计可为推动消除病毒性肝炎提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Research 医学-胃肠肝病学

CiteScore

8.30

自引率

14.30%

发文量

124

审稿时长

1 months

期刊介绍： Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.