Pharmacodynamic Target Attainment at Infection Site During Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Klebsiella pneumoniae with Ceftazidime–Avibactam–Based Regimens: a case report
Yinru Chen , Wanzhen Li , Xiaofen Liu , Yan Chen , Jing Zhang , Nanyang Li , Lei Yang
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引用次数: 0
Abstract
A patient developed a post-neurosurgical ventriculitis with carbapenem-resistant Klebsiella pneumoniae and mold, initially treated with ceftazidime/avibactam and voriconazole. A Klebsiella pneumoniae carbapenemase mutation led to therapy adjustment to ceftazidime/avibactam and polymyxin B, achieving cure. Pharmacokinetic/pharmacodynamic analysis highlights effective ceftazidime/avibactam brain penetration and bacterial clearance efficacy.
期刊介绍：
The International Journal of Antimicrobial Agents is a peer-reviewed publication offering comprehensive and current reference information on the physical, pharmacological, in vitro, and clinical properties of individual antimicrobial agents, covering antiviral, antiparasitic, antibacterial, and antifungal agents. The journal not only communicates new trends and developments through authoritative review articles but also addresses the critical issue of antimicrobial resistance, both in hospital and community settings. Published content includes solicited reviews by leading experts and high-quality original research papers in the specified fields.
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