Duration of a standard phototherapy course in jaundiced newborns with no neurotoxicity risk.

IF 1.8 4区 医学 Q2 PEDIATRICS Journal of Tropical Pediatrics Pub Date : 2024-10-04 DOI:10.1093/tropej/fmae037
Serdar Ümit Sarici, Kübra Arslan, Altay Babacan, Demet Soylu, Ayca Törel Ergür, Muhittin Abdulkadir Serdar, Dilek Sarici
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Abstract

In this study, we aimed to determine an ordinary/empiric/standard phototherapy treatment protocol for duration without controlling total serum bilirubin (TSB) levels after initiating phototherapy in early-term and full-term jaundiced newborns who had no hyperbilirubinemia neurotoxicity risk factors. We compared two groups, each receiving either 24 h (Group I) or 18 h (Group II) of continuous phototherapy in terms of demographic characteristics and efficacy (rate of decrease in TSB levels with phototherapy). No control TSB measurements were performed in the study groups until the end of phototherapy for the predetermined durations. Declines in TSB after phototherapy were significantly greater in Group I than in Group II, both in terms of mg/dl (11.81 ± 2.93 mg/dl vs. 10.75 ± 2.48 mg/dl, P = .0008) and percentage (56.71 ± 9.06% vs. 52.86 ± 8.37%, P = .0002). However, the rate of TSB reduction after phototherapy in mg/dl/h (0.59 ± 0.13 mg/dl/h vs. 0.49 ± 0.12 mg/dl/h, P = <.0001) and percentage per hour (2.93 ± 0.37% vs. 2.36 ± 0.46%, P = <.0001) were significantly higher in Group II than in Group I. This indicates an inverse time-response relationship between the duration of phototherapy and the response rate in the study groups. Although the 24-h phototherapy course showed greater efficacy concerning the primary bilirubin outcome measures (decline in TSB in mg/dl and %), the 18-h course of phototherapy treatment provided better hourly outcomes and reached its saturation point around the 18th hour. Therefore, an 18-h phototherapy without TSB monitoring until the end of the phototherapy should be considered for jaundiced newborns lacking neurotoxicity risk factors.

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黄疸新生儿标准光疗疗程的持续时间,无神经毒性风险。
在本研究中,我们旨在确定一种普通/经验/标准光疗方案,该方案适用于无高胆红素血症神经毒性风险因素的早产和足月黄疸新生儿,在开始光疗后不控制血清总胆红素(TSB)水平。我们比较了两组新生儿的人口统计学特征和疗效(光疗后 TSB 水平的下降率),每组分别接受 24 小时(I 组)或 18 小时(II 组)的连续光疗。研究组在预定时间的光疗结束前不进行 TSB 对照测量。光疗后,I 组 TSB 的降幅明显高于 II 组,无论是毫克/分升(11.81 ± 2.93 毫克/分升 vs. 10.75 ± 2.48 毫克/分升,P = .0008)还是百分比(56.71 ± 9.06% vs. 52.86 ± 8.37%,P = .0002)。然而,光疗后 TSB 的降低率以 mg/dl/h 为单位(0.59 ± 0.13 mg/dl/h vs. 0.49 ± 0.12 mg/dl/h,P = 0.0002)。
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来源期刊
Journal of Tropical Pediatrics
Journal of Tropical Pediatrics 医学-热带医学
CiteScore
4.00
自引率
0.00%
发文量
97
审稿时长
6-12 weeks
期刊介绍: The Journal of Tropical Pediatrics provides a link between theory and practice in the field. Papers report key results of clinical and community research, and considerations of programme development. More general descriptive pieces are included when they have application to work preceeding elsewhere. The journal also presents review articles, book reviews and, occasionally, short monographs and selections of important papers delivered at relevant conferences.
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