Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats.

IF 2.4 4区 医学 Q3 NEUROSCIENCES Neuroscience Research Pub Date : 2024-10-09 DOI:10.1016/j.neures.2024.10.001
Tyler J Gustafson, Lauren E McGrath, Matthew R Hayes, Elizabeth G Mietlicki-Baase
{"title":"Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats.","authors":"Tyler J Gustafson, Lauren E McGrath, Matthew R Hayes, Elizabeth G Mietlicki-Baase","doi":"10.1016/j.neures.2024.10.001","DOIUrl":null,"url":null,"abstract":"<p><p>The pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents. We evaluated whether VTA amylin signaling governs feeding and body weight in female rats. Indeed, pharmacological VTA AmyR activation suppressed chow intake and body weight in females. Viral-mediated knockdown of VTA calcitonin receptor (GPCR of AmyR) supports the physiological relevance of VTA amylin signaling for energy balance control in females. Collectively, these data support the relevance of VTA amylin signaling for energy balance control in both sexes.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neures.2024.10.001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

The pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents. We evaluated whether VTA amylin signaling governs feeding and body weight in female rats. Indeed, pharmacological VTA AmyR activation suppressed chow intake and body weight in females. Viral-mediated knockdown of VTA calcitonin receptor (GPCR of AmyR) supports the physiological relevance of VTA amylin signaling for energy balance control in females. Collectively, these data support the relevance of VTA amylin signaling for energy balance control in both sexes.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
腹侧被盖区淀粉样蛋白/降钙素受体信号传导可抑制雌性大鼠的摄食和体重增加。
胰腺肽淀粉样蛋白促进能量负平衡的部分原因是通过激活腹侧被盖区(VTA)表达的淀粉样蛋白受体(AmyRs),但相关研究仅限于雄性啮齿动物。我们评估了腹侧被盖区淀粉样蛋白信号是否会影响雌性大鼠的摄食和体重。事实上,药物激活VTA淀粉酶抑制了雌鼠的进食量和体重。病毒介导的 VTA 降钙素受体(AmyR 的 GPCR)敲除支持了 VTA 淀粉素信号在雌鼠能量平衡控制中的生理相关性。总之,这些数据支持VTA淀粉样蛋白信号与两性能量平衡控制的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
期刊最新文献
LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats. Stress and parental behaviors. Spatial dynamics of spontaneous activity in the developing and adult cortices. Detailed analysis of drift diffusion model parameters estimated for the ultimatum game. Cell type census in cerebral cortex reveals species-specific brain function and connectivity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1