Efficacy and safety of endoscopic subserosal dissection treatment for gastrointetinal submucosal tumors in the upper gastrointestinal tract.

IF 1.6 3区医学 Q2 SURGERY BMC Surgery Pub Date : 2024-10-10 DOI:10.1186/s12893-024-02592-z

Aili Wang, Qiong Niu, Yan Chen, Lijuan Liu, Xin Xiao, Chengxia Liu

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Abstract

Objective: To investigate the safety and efficacy of endoscopic subserosal dissection for patients with submucosal tumors in the upper gastrointestinal tract.

Methods: This retrospective single-center study included 16 patients who underwent ESSD. All patients were enrolled from July 2018 to Dec 2021. Parameters such as demographics, size, resection margin, complications, pathological features, procedure time and follow-up were investigated and analyzed.

Results: Our study achieved 100% en bloc resection and 100% R0 resection. The most common location was the corpus with a mean tumor size of 2.78 ± 1.56 cm. The mean age, procedure time, were 53.4 ± 10.3 years, 85.31 ± 46.64 min respectively. Acocording to National Institutes of Health classification, 7 (13, 53.85%), 5 (13, 38.46%) ,and 1 (13, 7.69%) objects belonged to the very low, low, and intermediate classification, respectively. Immunohistochemistry results showed a 100% positive rate of CD34, DOG-1, CD117, and Ki67. A mean follow-up of 9.3 ± 2.5 months showed no recurrence or metastasis.

Conclusions: ESSD is effective and safe surgical procedure for curative removal of gastrointestinal submucosal tumors in the upper gastrointestinal tract, and it can be preferred for patients with no metastasis.

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内镜下粘膜下剥离术治疗上消化道胃网状粘膜下肿瘤的有效性和安全性。

目的研究上消化道粘膜下肿瘤患者接受内镜下粘膜下剥离术的安全性和有效性：这项回顾性单中心研究纳入了16例接受ESSD的患者。所有患者的入组时间为2018年7月至2021年12月。对人口统计学、肿瘤大小、切除边缘、并发症、病理特征、手术时间和随访等参数进行了调查和分析：我们的研究实现了100%的全切和100%的R0切除。最常见的肿瘤位置是冠状沟，平均肿瘤大小为（2.78 ± 1.56）厘米。平均年龄（53.4±10.3）岁，平均手术时间（85.31±46.64）分钟。根据美国国立卫生研究院的分类，7 例（13 例，53.85%）、5 例（13 例，38.46%）和 1 例（13 例，7.69%）分别属于极低级、低级和中级。免疫组化结果显示，CD34、DOG-1、CD117 和 Ki67 的阳性率均为 100%。平均随访 9.3 ± 2.5 个月，未发现复发或转移：上消化道黏膜下肿瘤切除术（ESSD）是根治性切除上消化道胃黏膜下肿瘤的有效而安全的手术方法，无转移的患者可首选该方法。

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