Sustainable bioinspired materials for regenerative medicine: balancing toxicology, environmental impact, and ethical considerations.

Ajay Vikram Singh, Vaisali Chandrasekar, Varsha M Prabhu, Jolly Bhadra, Peter Laux, Preeti Bhardwaj, Abdulla A Al-Ansari, Omar M Aboumarzouk, Andreas Luch, Sarada Prasad Dakua
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Abstract

The pursuit of sustainable bioinspired materials in regenerative medicine necessitates a delicate equilibrium between scientific innovation, ethical mindfulness, and environmental responsibility. This abstract encapsulates the essence of a comprehensive perspective paper that explores the intricate interplay of toxicology, environmental impact, and ethical considerations in the realm of bioinspired materials. As the regenerative medicine landscape continues to evolve, the evaluation of biocompatibility and safety of bioinspired materials emerges as a critical concern. This paper delves into the multidimensional aspects of toxicity assessment, encompassing cytotoxicity, genotoxicity, and immunotoxicity analyses. Moreover, it sheds light on the challenging task of evaluating the environmental repercussions of these materials, elucidating methodologies such as life cycle assessment, biodegradability testing, and sustainable design approaches. Amid these scientific endeavors, the ethical dimensions of bioinspired material development remain paramount. The paper navigates the complex web of international regulations and ethical frameworks guiding medical materials, emphasizing the importance of aligning innovation with ethical standards. Furthermore, the abstract highlights the envisioned future directions and challenges in toxicology techniques, computational modeling, and holistic evaluation, culminating in a holistic understanding of the synergistic interplay between sustainable bioinspired materials, toxicity assessment, environmental stewardship, and ethical deliberation. .

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用于再生医学的可持续生物启发材料:平衡毒理学、环境影响和伦理考虑。
在再生医学领域追求可持续的生物启发材料,需要在科学创新、道德意识和环境责任之间取得微妙的平衡。本摘要概括了一篇综合视角论文的精髓,探讨了生物启发材料领域中毒理学、环境影响和伦理考虑之间错综复杂的相互作用。随着再生医学领域的不断发展,生物启发材料的生物相容性和安全性评估成为了一个重要的关注点。本文深入探讨了毒性评估的多维方面,包括细胞毒性、遗传毒性和免疫毒性分析。此外,论文还阐明了评估这些材料对环境影响的挑战性任务,阐明了生命周期评估、生物降解性测试和可持续设计方法等方法。在这些科学努力中,生物启发材料开发的伦理层面仍然至关重要。论文探讨了指导医疗材料的国际法规和伦理框架的复杂网络,强调了创新与伦理标准相一致的重要性。此外,摘要还强调了毒理学技术、计算建模和整体评估方面的未来发展方向和挑战,最终对可持续生物启发材料、毒性评估、环境管理和伦理审议之间的协同作用有了全面的了解。
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