[Fatal course of a fulminant gas gangrene of the right hemithorax].

Christoph J Neumann, Matthias Unterberg, Daniel Mesbah, Mark Sandfort, Rüdiger Smektala
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Abstract

The full clinical picture of a gas gangrene infection is an absolute rarity. The mechanism of development can be either traumatic or spontaneous (e.g., hematogenous seeding in occult colon carcinoma). In particular, the rare pathogen Clostridium septicum appears to be associated with spontaneously occurring gas gangrene. Diabetes mellitus is a significant risk factor. The mortality rate of the disease is around 50%, even with maximum therapeutic efforts, and the course of the disease is fulminant in the majority of cases. Initial symptoms are unspecific and make early diagnosis difficult. Treatment consists of high-dose antibiotics in combination with radical surgical debridement and, if necessary, supplementary hyperbaric oxygen therapy.

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[右半胸暴发性气性坏疽的致命病程]。
气性坏疽感染的完整临床表现绝对罕见。其发病机制可以是创伤性的,也可以是自发性的(如隐匿性结肠癌的血源性播散)。特别是,罕见的病原体败血梭菌似乎与自发性气性坏疽有关。糖尿病是一个重要的危险因素。即使尽最大努力进行治疗,该病的死亡率也在 50%左右,而且大多数病例的病程都是急性的。最初的症状没有特异性,因此很难进行早期诊断。治疗包括大剂量抗生素治疗和根治性手术清创,必要时还需要辅助高压氧治疗。
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